SCP2 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 10856712)
0

Data Source:
HPRD (in vitro)

		SCP2	EHHADH
Description		sterol carrier protein 2	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Phospholipid Transport Sterol Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Phospholipid Biosynthetic Process Protein Localization To Plasma Membrane Intermembrane Lipid Transfer Lipid Hydroperoxide Transport Fatty Acid Derivative Biosynthetic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways		alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases		Leukoencephalopathy with dystonia and motor neuropathy Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS			Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		11 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CEBPA CREB3 EHHADH OGT PEX5 PITPNA TRIP13	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		6342	1962
HPRD ID		01700	06125
Ensembl ID		ENSG00000116171	ENSG00000113790
Uniprot IDs		A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9	Q08426
PDB IDs		1QND 2C0L
Enriched GO Terms of Interacting Partners?		Fatty Acid Beta-oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Metabolic Process Lipid Modification Peroxisomal Matrix Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Peroxisome Lipid Homeostasis Monocarboxylic Acid Metabolic Process Regulation Of Necroptotic Process Cellular Response To Stress Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Programmed Necrotic Cell Death Integrated Stress Response Signaling Organelle Organization Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Mitochondrion Organization Very Long-chain Fatty Acid Beta-oxidation Inward Rectifier Potassium Channel Inhibitor Activity Membrane Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Peroxisomal Membrane Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Protein-containing Complex Negative Regulation Of Protein Ubiquitination Fatty Acid Derivative Metabolic Process Small Molecule Metabolic Process Response To Stress Caveolar Macromolecular Signaling Complex Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Peroxisome Membrane Targeting Sequence Binding	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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