SCP2 and TRIP13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SCP2	TRIP13
Description		sterol carrier protein 2	thyroid hormone receptor interactor 13
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex	Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity	Nucleotide Binding Transcription Coregulator Activity Protein Binding ATP Binding ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Phospholipid Transport Sterol Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Phospholipid Biosynthetic Process Protein Localization To Plasma Membrane Intermembrane Lipid Transfer Lipid Hydroperoxide Transport Fatty Acid Derivative Biosynthetic Process	Oocyte Maturation Double-strand Break Repair Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Cell Differentiation Oogenesis Meiotic Cell Cycle Meiotic Recombination Checkpoint Signaling
Pathways		alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs
Diseases		Leukoencephalopathy with dystonia and motor neuropathy Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS			Pancreatic cancer ( 25086665)
Interacting Genes		11 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CEBPA CREB3 EHHADH OGT PEX5 PITPNA TRIP13	113 interacting genes: ACTMAP ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BKGD BUB1B C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FILNC1 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPMIP9 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655
Entrez ID		6342	9319
HPRD ID		01700	05145
Ensembl ID		ENSG00000116171	ENSG00000071539
Uniprot IDs		A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9	Q15645
PDB IDs		1QND 2C0L	5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P
Enriched GO Terms of Interacting Partners?		Fatty Acid Beta-oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Metabolic Process Lipid Modification Peroxisomal Matrix Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Peroxisome Lipid Homeostasis Monocarboxylic Acid Metabolic Process Regulation Of Necroptotic Process Cellular Response To Stress Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Programmed Necrotic Cell Death Integrated Stress Response Signaling Organelle Organization Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Mitochondrion Organization Very Long-chain Fatty Acid Beta-oxidation Inward Rectifier Potassium Channel Inhibitor Activity Membrane Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Peroxisomal Membrane Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Protein-containing Complex Negative Regulation Of Protein Ubiquitination Fatty Acid Derivative Metabolic Process Small Molecule Metabolic Process Response To Stress Caveolar Macromolecular Signaling Complex Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Peroxisome Membrane Targeting Sequence Binding	Protein Binding Mitotic Checkpoint Complex Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Protein K6-linked Ubiquitination Intermediate Filament
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