SCP2 and ACOX1

Number of citations: 0 (PubMedID 10856712)
Data Source: HPRD (in vitro)

		SCP2	ACOX1
Name		sterol carrier protein 2	acyl-CoA oxidase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity	Acyl-CoA Oxidase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors PDZ Domain Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding FAD Binding Long-chain Fatty Acyl-CoA Oxidase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Phospholipid Transport Sterol Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Phospholipid Biosynthetic Process Protein Localization To Plasma Membrane Intermembrane Lipid Transfer Lipid Hydroperoxide Transport Fatty Acid Derivative Biosynthetic Process	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Spermatogenesis Fatty Acid Catabolic Process Peroxisome Fission Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Cholesterol Homeostasis Long-chain Fatty Acid Biosynthetic Process Hydrogen Peroxide Biosynthetic Process Lipid Homeostasis Very Long-chain Fatty Acid Beta-oxidation Fatty Acid Derivative Biosynthetic Process
Pathways		alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		None	Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases		Leukoencephalopathy with dystonia and motor neuropathy Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia	Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		No GWAS studies recorded	Body mass index ( 28552196 ) Diastolic blood pressure ( 27841878 ) Mean platelet volume ( 32888494 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 28135244 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) White matter hyperintensities ( 30002152 ) White matter hyperintensity burden ( 25663218 )
Interacting Genes		11 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CEBPA CREB3 EHHADH OGT PEX5 PITPNA TRIP13	4 interacting genes: OGT SCP2 SLC2A4 TYSND1
Entrez ID		6342	51
HPRD ID		01700	02030
Ensembl ID		ENSG00000116171	ENSG00000161533
Uniprot IDs		A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9	Q15067
PDB IDs		1QND 2C0L	Not available
GO Terms Enriched among Interactors		Fatty Acid Beta-oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Metabolic Process Lipid Modification Peroxisomal Matrix Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Peroxisome Lipid Homeostasis Monocarboxylic Acid Metabolic Process Regulation Of Necroptotic Process Cellular Response To Stress Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Programmed Necrotic Cell Death Integrated Stress Response Signaling Organelle Organization Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Mitochondrion Organization Very Long-chain Fatty Acid Beta-oxidation Inward Rectifier Potassium Channel Inhibitor Activity Membrane Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Peroxisomal Membrane Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Protein-containing Complex Negative Regulation Of Protein Ubiquitination Fatty Acid Derivative Metabolic Process Small Molecule Metabolic Process Response To Stress Caveolar Macromolecular Signaling Complex Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Peroxisome Membrane Targeting Sequence Binding	Regulation Of Lipid Metabolic Process Peroxisomal Matrix Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Peroxisome Positive Regulation Of Lipid Metabolic Process Lipid Hydroperoxide Transport Oleic Acid Binding Acetyl-CoA C-myristoyltransferase Activity Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Response To Insulin Protein Processing Protein O-acetylglucosaminyltransferase Activity Regulation Of Lipid Biosynthetic Process Long-chain Fatty Acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Positive Regulation Of Intracellular Lipid Transport Carbohydrate Homeostasis Glucose Homeostasis White Fat Cell Proliferation Progesterone Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Phosphatidylcholine Transfer Activity Inositol Trisphosphate Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Intracellular Cholesterol Transport Dehydroascorbic Acid Transport Response To Peptide Hormone Fat Cell Proliferation Protein Maturation Regulation Of Intracellular Lipid Transport Regulation Of Transcription By Glucose Regulation Of Small Molecule Metabolic Process Lipid Binding D-glucose Transmembrane Transporter Activity C21-steroid Hormone Biosynthetic Process Phosphatidylinositol Transfer Activity NSL Complex