PPM1A and CACNA1A

Number of citations of the paper that reports this interaction (PMID 15728831)
6

Data Source:
HPRD (in vivo, in vitro)

		PPM1A	CACNA1A
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Neuron Projection	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of SMAD Protein Complex Assembly Wnt Signaling Pathway Dephosphorylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS		Allergic rhinitis ( 22036096)
Protein-Protein Interactions		19 interactors: AKT1 CACNA1A CACNA1B CACNA1C CTNNB1 DVL1 DVL2 DVL3 EEF2 FGFR2 GRM3 HSPB1 MSN NR4A1 PIK3R1 PRKCD RPLP0 SMAD2 SMAD3	92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		5494	773
HPRD ID		16199	03004
Ensembl ID		ENSG00000100614	ENSG00000141837
Uniprot IDs		B2R8E4 P35813	B5TYJ1 O00555 Q9NS89
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO	3BXK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Canonical Wnt Signaling Pathway Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Embryonic Organ Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Death Posttranscriptional Regulation Of Gene Expression Signaling Negative Regulation Of Signal Transduction Cell Communication Heart Development Negative Regulation Of Cellular Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Planar Cell Polarity Pathway Involved In Neural Tube Closure Neural Plate Development Digestive Tract Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Embryonic Foregut Morphogenesis Positive Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Foregut Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell-cell Signaling Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Organ Development Response To Fibroblast Growth Factor Embryonic Morphogenesis Regulation Of Catalytic Activity	Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Intersection) ?