PPM1A

Description		protein phosphatase, Mg2+/Mn2+ dependent 1A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Protein Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		38 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MID1 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3
Entrez ID		5494
HPRD ID		16199
Ensembl ID		ENSG00000100614
Uniprot IDs		B2R8E4 P35813
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Nucleotide Binding Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Transferase Activity Intracellular Signal Transduction Receptor Complex Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Cell Migration Negative Regulation Of Programmed Cell Death Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Protein Autophosphorylation Regulation Of Apoptotic Process Cell Motility Regulation Of Protein Localization Regulation Of Epithelial Cell Proliferation Regulation Of Programmed Cell Death Cell-cell Junction Protein Serine/threonine Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Plasma Membrane Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization
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