PPM1A and GRM3

Number of citations of the paper that reports this interaction (PMID 14663150)
12

Data Source:
HPRD (in vitro)

		PPM1A	GRM3
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1A	glutamate receptor, metabotropic 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Neuron Projection	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Presynaptic Membrane Dendritic Spine Postsynaptic Membrane Astrocyte Projection
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding	Group II Metabotropic Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of SMAD Protein Complex Assembly Wnt Signaling Pathway Dephosphorylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096)	Brachial circumference ( 22479309)
Protein-Protein Interactions		19 interactors: AKT1 CACNA1A CACNA1B CACNA1C CTNNB1 DVL1 DVL2 DVL3 EEF2 FGFR2 GRM3 HSPB1 MSN NR4A1 PIK3R1 PRKCD RPLP0 SMAD2 SMAD3	6 interactors: CALM1 GRASP GRIP1 PICK1 PPM1A SDCBP
Entrez ID		5494	2913
HPRD ID		16199	03070
Ensembl ID		ENSG00000100614	ENSG00000198822
Uniprot IDs		B2R8E4 P35813	A4D1D0 B7Z204 F5GYZ2 Q14832
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO	1S8M 3SM9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Canonical Wnt Signaling Pathway Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Embryonic Organ Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Death Posttranscriptional Regulation Of Gene Expression Signaling Negative Regulation Of Signal Transduction Cell Communication Heart Development Negative Regulation Of Cellular Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Planar Cell Polarity Pathway Involved In Neural Tube Closure Neural Plate Development Digestive Tract Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Embryonic Foregut Morphogenesis Positive Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Foregut Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell-cell Signaling Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Organ Development Response To Fibroblast Growth Factor Embryonic Morphogenesis Regulation Of Catalytic Activity	Synaptic Transmission Cell-cell Signaling Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Transport Protein Localization Membrane Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Neuron Development Negative Regulation Of SMAD Protein Complex Assembly Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cellular Localization Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Methylation Involved In Embryo Development Neuron Differentiation Cell Projection Organization N-terminal Protein Myristoylation Dendritic Spine Maintenance Protein Myristoylation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Calcium Ion Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Peptidyl-threonine Dephosphorylation Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Phosphoprotein Phosphatase Activity Protein Localization To Membrane Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?