PPM1A and DVL3

Number of citations of the paper that reports this interaction (PMID 10644691)
17

Data Source:
HPRD (in vivo)

		PPM1A	DVL3
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1A	dishevelled segment polarity protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Neuron Projection	Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of SMAD Protein Complex Assembly Wnt Signaling Pathway Dephosphorylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096)	Major depressive disorder ( 22472876)
Protein-Protein Interactions		19 interactors: AKT1 CACNA1A CACNA1B CACNA1C CTNNB1 DVL1 DVL2 DVL3 EEF2 FGFR2 GRM3 HSPB1 MSN NR4A1 PIK3R1 PRKCD RPLP0 SMAD2 SMAD3	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		5494	1857
HPRD ID		16199	03222
Ensembl ID		ENSG00000100614	ENSG00000161202
Uniprot IDs		B2R8E4 P35813	Q92997
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Canonical Wnt Signaling Pathway Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Embryonic Organ Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Death Posttranscriptional Regulation Of Gene Expression Signaling Negative Regulation Of Signal Transduction Cell Communication Heart Development Negative Regulation Of Cellular Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Planar Cell Polarity Pathway Involved In Neural Tube Closure Neural Plate Development Digestive Tract Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Embryonic Foregut Morphogenesis Positive Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Foregut Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell-cell Signaling Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Organ Development Response To Fibroblast Growth Factor Embryonic Morphogenesis Regulation Of Catalytic Activity	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?