PPM1A and RPLP0

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PPM1A	RPLP0
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1A	ribosomal protein, large, P0
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Neuron Projection	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of SMAD Protein Complex Assembly Wnt Signaling Pathway Dephosphorylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosome Biogenesis Cellular Protein Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096)
Protein-Protein Interactions		19 interactors: AKT1 CACNA1A CACNA1B CACNA1C CTNNB1 DVL1 DVL2 DVL3 EEF2 FGFR2 GRM3 HSPB1 MSN NR4A1 PIK3R1 PRKCD RPLP0 SMAD2 SMAD3	11 interactors: CCNDBP1 CSNK2A1 ERG GAS7 KRI1 PAFAH1B2 PPM1A PRPF40A SMAD3 STAU1 YWHAQ
Entrez ID		5494	6175
HPRD ID		16199	01610
Ensembl ID		ENSG00000100614	ENSG00000089157
Uniprot IDs		B2R8E4 P35813	P05388 Q3B7A4
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO	3J39 3J3B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Canonical Wnt Signaling Pathway Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Embryonic Organ Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Death Posttranscriptional Regulation Of Gene Expression Signaling Negative Regulation Of Signal Transduction Cell Communication Heart Development Negative Regulation Of Cellular Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Planar Cell Polarity Pathway Involved In Neural Tube Closure Neural Plate Development Digestive Tract Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Embryonic Foregut Morphogenesis Positive Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Foregut Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell-cell Signaling Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Organ Development Response To Fibroblast Growth Factor Embryonic Morphogenesis Regulation Of Catalytic Activity	Regulation Of Cell Cycle Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle Arrest Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Potassium Ion Export Cell Cycle Process Regulation Of Transcription Factor Import Into Nucleus Regulation Of Intracellular Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regulation Of Heart Rate By Hormone Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Negative Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Cell Shape Negative Regulation Of SMAD Protein Complex Assembly Regulation Of Extracellular Matrix Assembly Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Import Into Nucleus Regulation Of Establishment Of Protein Localization Primary MiRNA Processing Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Nucleocytoplasmic Transport N-terminal Protein Myristoylation Regulation Of Transcription, DNA-templated Regulation Of Protein Localization Negative Regulation Of Mitotic Cell Cycle Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	3months 60s brains brdu bromodeoxyuridine cacybp calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside pk postnatal proteomic pyruvate spots tk transketolase ts1cje
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	3months 60s brains brdu bromodeoxyuridine cacybp calcyclin candidates comparative diphosphate disabilities ds dysregulated e14 embryos eminence fingerprinting ganglionic ndpk nucleoside pk postnatal proteomic pyruvate spots tk transketolase ts1cje
Tagcloud (Intersection) ?