CA9 and GLRX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		CA9	GLRX3
Description		carbonic anhydrase 9	glutaredoxin 3
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Plasma Membrane Membrane Basolateral Plasma Membrane Microvillus Membrane Cell Projection	Nucleus Cytoplasm Cytosol Cell Cortex Z Disc Dendrite Iron-sulfur Cluster Assembly Complex
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding Molecular Function Activator Activity	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Response To Hypoxia Morphogenesis Of An Epithelium Response To Xenobiotic Stimulus Response To Testosterone Secretion	Regulation Of The Force Of Heart Contraction Intracellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Reversible hydration of carbon dioxide	Iron uptake and transport
Drugs		Benzthiazide Benzthiazide Cyclothiazide Hydroflumethiazide Zonisamide Girentuximab Ellagic acid Sodium carbonate DTP-348
Diseases
GWAS			Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		6 interacting genes: CAND1 CDH1 CSRP1 CTNNA1 CTNNB1 GLRX3	99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CEBPA CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774
Entrez ID		768	10539
HPRD ID		04417	10153
Ensembl ID		ENSG00000107159	ENSG00000108010
Uniprot IDs		A0A0S2Z341 A0A0S2Z3D0 Q16790	A0A140VJK1 O76003
PDB IDs		2HKF 3IAI 5DVX 5FL4 5FL5 5FL6 6FE0 6FE1 6FE2 6G98 6G9U 6QN2 6QN5 6QN6 6QUT 6RQN 6RQQ 6RQU 6RQW 6TL5 6TL6 6Y74 7POM 8CO0 8Q18 8Q19 8Q1A	2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Cellular Response To Indole-3-methanol Response To Indole-3-methanol Flotillin Complex Catenin Complex Negative Regulation Of Cell Development Gamma-catenin Binding Cell-cell Junction Assembly Negative Regulation Of Neurogenesis Z Disc Negative Regulation Of Nervous System Development Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Negative Regulation Of Multicellular Organismal Process Cell-cell Junction Organization Regulation Of Protein Sumoylation Adherens Junction Lamellipodium Disordered Domain Specific Binding Cell Junction Apical Junction Complex Negative Regulation Of Cell Differentiation Cell-cell Adhesion Mediated By Cadherin Response To Alcohol Cell Junction Assembly Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Regulation Of Cell Development Cadherin Binding Cell Adhesion Adherens Junction Organization Cellular Response To Oxygen-containing Compound Apoptotic Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Developmental Process Lateral Plasma Membrane Regulation Of Neurogenesis Odontogenesis Of Dentin-containing Tooth Ligase Inhibitor Activity Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Anchoring Junction Focal Adhesion Regulation Of Nervous System Development Negative Regulation Of Post-translational Protein Modification Beta-catenin Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Cell Junction Organization Epidermal Cell Differentiation	Intermediate Filament Keratin Filament Hair Cycle Iron-sulfur Cluster Assembly Protein Binding Iron-sulfur Cluster Assembly Complex Identical Protein Binding
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