CA9 and CTNNA1

Number of citations of the paper that reports this interaction (PMID 14567991)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		CA9	CTNNA1
Gene Name		carbonic anhydrase IX	catenin (cadherin-associated protein), alpha 1, 102kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Microvillus Membrane	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Lamellipodium
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding	Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Poly(A) RNA Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Morphogenesis Of An Epithelium One-carbon Metabolic Process Bicarbonate Transport Response To Testosterone Response To Drug Small Molecule Metabolic Process Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Muscle Cell Differentiation Apical Junction Assembly Response To Estrogen Cell-cell Junction Organization Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Reversible hydration of carbon dioxide Regulation of gene expression by Hypoxia-inducible Factor	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CDH1 CTNNA1 CTNNB1	27 interactors: ACTN1 AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CTBP1 CTNNB1 DLG1 FAM84B JUP MLLT4 PKD1 PSEN1 RNF219 SPTAN1 SPTBN1 SUMO1 TJP1 TJP2 VCL ZGPAT
Entrez ID		768	1495
HPRD ID		04417	00285
Ensembl ID		ENSG00000107159	ENSG00000044115
Uniprot IDs		Q16790	P35221
PDB IDs		2HKF 3IAI	1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?		Cellular Response To Indole-3-methanol Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Regulation Of Protein Localization To Cell Surface Cellular Response To Organic Cyclic Compound Protein Oligomerization Regulation Of Neuroblast Proliferation Cellular Response To Organonitrogen Compound Single Organismal Cell-cell Adhesion Epithelial Cell Morphogenesis Apical Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Morphogenesis Of A Branching Structure Negative Regulation Of Cell Proliferation Regulation Of Neurogenesis Execution Phase Of Apoptosis Positive Regulation Of Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Regulation Of Neural Precursor Cell Proliferation Response To Organonitrogen Compound Regulation Of Cell Development Lens Development In Camera-type Eye Regulation Of Stem Cell Proliferation Response To Organic Cyclic Compound Cell-cell Junction Assembly Odontogenesis Protein Heterooligomerization Organ Morphogenesis Protein Complex Assembly Negative Regulation Of Signal Transduction Digestive Tract Development Neuron Differentiation Digestive System Development Negative Regulation Of Signaling Cell Adhesion Regulation Of Muscle Cell Differentiation Tube Formation Synapse Organization Male Sex Differentiation Regulation Of Organ Morphogenesis Cellular Protein Localization Response To Estrogen Epithelial Cell Development Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Integrin-mediated Signaling Pathway Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus	Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cell Adhesion Cellular Component Assembly Epithelium Development Developmental Process Anatomical Structure Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Execution Phase Of Apoptosis Adherens Junction Assembly Cell Differentiation Tissue Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Development Cellular Response To Indole-3-methanol Establishment Of Endothelial Barrier Apical Junction Assembly Anatomical Structure Morphogenesis Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Complex Assembly Regulation Of Cellular Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Skin Development Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Endothelial Cell Development Tight Junction Assembly Positive Regulation Of Protein Metabolic Process Locomotion Endomembrane System Organization Neurogenesis Apoptotic Process Regulation Of Epithelial Cell Proliferation Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Programmed Cell Death Morphogenesis Of An Epithelium Cell Death Death Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Endothelial Cell Differentiation Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization
Tagcloud ?		8505c adenocarcinoma bmp bmps calcified disclosed gingival hsc hsg katoiii masses mkn45 mnk45 morphogenetic neoplastic nude osteogenesis possessed rcm rectal rest s8 salivary signet solely squamous t24 tongue weakly	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Difference) ?		8505c adenocarcinoma bmp bmps calcified disclosed gingival hsc hsg katoiii masses mkn45 mnk45 morphogenetic neoplastic nude osteogenesis possessed rcm rectal rest s8 salivary signet solely squamous t24 tongue weakly	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Intersection) ?