GLRX3 and ALKBH3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GLRX3	ALKBH3
Gene Name		glutaredoxin 3	alkB, alkylation repair homolog 3 (E. coli)
Image
Gene Ontology Annotations	Cellular Component	Cell Cortex Z Disc Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Kinase C Binding Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Poly(A) RNA Binding Metal Ion Binding Iron-sulfur Cluster Binding	Protein Binding Ferrous Iron Binding L-ascorbic Acid Binding DNA-N1-methyladenine Dioxygenase Activity Cytosine C-5 DNA Demethylase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Cell Redox Homeostasis Oxidation-reduction Process	DNA Repair DNA Dealkylation Involved In DNA Repair Cell Proliferation Oxidative Single-stranded DNA Demethylation
Pathways			ABH3 mediated Reversal of Alkylation Damage DNA Damage Reversal Reversal of Alkylation Damage By DNA Dioxygenases
Drugs
Diseases
GWAS		HIV-1 susceptibility ( 21160409)
Protein-Protein Interactions		57 interactors: ADAMTSL4 ALKBH3 BOLA1 CBLB CGGBP1 CIAPIN1 EFEMP2 FAM118A FRA10AC1 GMCL1 GRN HEXDC IKZF1 KRT31 KRT38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE2D MAP3K3 MAPK6 MAPKBP1 MOXD1 NADK NOTCH2NL OLFM3 PCSK5 PFDN5 PLSCR1 PRKCQ PRKCZ PRKD2 RGS20 SOX7 STAU1 TCF4 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF148 ZNF426 ZNF512B ZNF544	8 interactors: AK8 GLRX3 GOLGA2 IKZF1 LNX1 SRPK1 SRPK2 ZDHHC17
Entrez ID		10539	221120
HPRD ID		10153	16793
Ensembl ID		ENSG00000108010	ENSG00000166199
Uniprot IDs		O76003	Q96Q83
PDB IDs		2DIY 2WZ9 2YAN 3ZYW	2IUW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Positive Regulation Of Interleukin-4 Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Interleukin-4 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Activation Regulation Of T Cell Activation Cell Death Death Multicellular Organismal Development Positive Regulation Of Interleukin-2 Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Anatomical Structure Development Positive Regulation Of Neutrophil Differentiation Renin Secretion Into Blood Stream Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Process Transcription, DNA-templated Regulation Of T Cell Receptor Signaling Pathway Embryonic Digestive Tract Development Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction RNA Biosynthetic Process Regulation Of Lymphocyte Activation Protein Kinase D Signaling Positive Regulation Of T-helper 2 Cell Activation Oxidative Single-stranded DNA Demethylation Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Positive Regulation Of T Cell Activation	Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Viral Process Positive Regulation Of Neutrophil Differentiation Nuclear Speck Organization Regulation Of MRNA Processing Regulation Of RNA Splicing Nucleus Organization Regulation Of Viral Process Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Granulocyte Differentiation Sperm Chromatin Condensation Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy
Tagcloud ?			2og alkyl chromatin comprised demethylase dioxygenase display fe fto hits homologs hybrid interact marginally mediating modification oxoglutarate partners possess repairs rest reversal screens
Tagcloud (Difference) ?			2og alkyl chromatin comprised demethylase dioxygenase display fe fto hits homologs hybrid interact marginally mediating modification oxoglutarate partners possess repairs rest reversal screens
Tagcloud (Intersection) ?