GLRX3 and LRIG1

Number of citations: 61 (PubMedID 29317492)
Data Source: BioGRID (two hybrid)

		GLRX3	LRIG1
Name		glutaredoxin 3	leucine rich repeats and immunoglobulin like domains 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell Cortex Z Disc Dendrite Iron-sulfur Cluster Assembly Complex	Plasma Membrane Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Intracellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis	Sensory Perception Of Sound Hair Cycle Process Otolith Morphogenesis Innervation
Pathways		Iron uptake and transport	Signaling by EGFR Negative regulation of MET activity Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
GWAS		Alcohol dependence ( 26365420 ) Colorectal cancer ( 34062886 ) Copper levels ( 26025379 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) HIV-1 susceptibility ( 21160409 ) Mean corpuscular volume ( 32888494 ) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261 ) Sleep end time ( 33075057 ) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 )	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065 ) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065 ) Antibody status in Tripanosoma cruzi seropositivity ( 24324551 ) Atrial fibrillation ( 30061737 29892015 ) Birth weight ( 31043758 ) Blood urea nitrogen levels ( 29403010 ) Carotid intima media thickness ( 21909108 ) Chronic kidney disease ( 29124443 ) Colorectal cancer ( 26151821 ) Colorectal cancer or advanced adenoma ( 30510241 ) Creatinine levels ( 29124443 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 29124443 ) Hyperuricemia ( 29124443 ) Intraocular pressure ( 30054594 ) Iron status biomarkers (iron levels) ( 33536631 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Non-glioblastoma glioma ( 28346443 ) Orofacial clefts ( 33137956 ) Pulse pressure ( 27841878 ) QRS duration ( 27659466 27577874 21076409 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Renal function-related traits (BUN) ( 22797727 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Retinal detachment or retinal break ( 31816047 ) Serum uric acid levels ( 29124443 ) Systolic blood pressure ( 27841878 ) Type 2 diabetes ( 25760438 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Novel Interactors		1 novel interactors: REL	None recorded
Interacting Genes		99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CEBPA CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	5 interacting genes: CBL GLRX3 MICOS10-NBL1 NBL1 ZBTB16
Entrez ID		10539	26018
HPRD ID		10153	10057
Ensembl ID		ENSG00000108010	ENSG00000144749
Uniprot IDs		A0A140VJK1 O76003	Q96JA1
PDB IDs		2DIY 2WZ9 2YAN 3ZYW	4U7L 4U7M
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Hair Cycle Iron-sulfur Cluster Assembly Protein Binding Iron-sulfur Cluster Assembly Complex Identical Protein Binding	Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Regionalization Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Pattern Specification Process Maintenance Of Protein Location Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Maintenance Of Location Positive Regulation Of Neuron Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Identical Protein Binding Receptor Ligand Activity Type 2 Angiotensin Receptor Binding Regulation Of Mononuclear Cell Migration Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Rap Protein Signal Transduction Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Chemotaxis Ubiquitin-dependent Endocytosis Regulation Of Leukocyte Migration Regulation Of NK T Cell Differentiation System Development Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Ossification Involved In Bone Maturation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Mesonephros Development