CA9 and CDH1

Number of citations of the paper that reports this interaction (PMID 14567991)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CA9	CDH1
Gene Name		carbonic anhydrase IX	cadherin 1, type 1, E-cadherin (epithelial)
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Microvillus Membrane	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding
	Biological Process	Morphogenesis Of An Epithelium One-carbon Metabolic Process Bicarbonate Transport Response To Testosterone Response To Drug Small Molecule Metabolic Process Secretion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Reversible hydration of carbon dioxide Regulation of gene expression by Hypoxia-inducible Factor	Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)
Protein-Protein Interactions		3 interactors: CDH1 CTNNA1 CTNNB1	55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1
Entrez ID		768	999
HPRD ID		04417	01885
Ensembl ID		ENSG00000107159	ENSG00000039068
Uniprot IDs		Q16790	P12830 Q9UII8
PDB IDs		2HKF 3IAI	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Cellular Response To Indole-3-methanol Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Regulation Of Protein Localization To Cell Surface Cellular Response To Organic Cyclic Compound Protein Oligomerization Regulation Of Neuroblast Proliferation Cellular Response To Organonitrogen Compound Single Organismal Cell-cell Adhesion Epithelial Cell Morphogenesis Apical Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Morphogenesis Of A Branching Structure Negative Regulation Of Cell Proliferation Regulation Of Neurogenesis Execution Phase Of Apoptosis Positive Regulation Of Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Regulation Of Neural Precursor Cell Proliferation Response To Organonitrogen Compound Regulation Of Cell Development Lens Development In Camera-type Eye Regulation Of Stem Cell Proliferation Response To Organic Cyclic Compound Cell-cell Junction Assembly Odontogenesis Protein Heterooligomerization Organ Morphogenesis Protein Complex Assembly Negative Regulation Of Signal Transduction Digestive Tract Development Neuron Differentiation Digestive System Development Negative Regulation Of Signaling Cell Adhesion Regulation Of Muscle Cell Differentiation Tube Formation Synapse Organization Male Sex Differentiation Regulation Of Organ Morphogenesis Cellular Protein Localization Response To Estrogen Epithelial Cell Development Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Integrin-mediated Signaling Pathway Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus	Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		8505c adenocarcinoma bmp bmps calcified disclosed gingival hsc hsg katoiii masses mkn45 mnk45 morphogenetic neoplastic nude osteogenesis possessed rcm rectal rest s8 salivary signet solely squamous t24 tongue weakly	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		8505c adenocarcinoma bmp bmps calcified disclosed gingival hsc hsg katoiii masses mkn45 mnk45 morphogenetic neoplastic nude osteogenesis possessed rcm rectal rest s8 salivary signet solely squamous t24 tongue weakly	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?