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GLRX3 and HEXDC
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GLRX3
HEXDC
Gene Name
glutaredoxin 3
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cell Cortex
Z Disc
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Molecular Function
Protein Kinase C Binding
Protein Binding
Electron Carrier Activity
Protein Disulfide Oxidoreductase Activity
Poly(A) RNA Binding
Metal Ion Binding
Iron-sulfur Cluster Binding
Beta-N-acetylhexosaminidase Activity
Biological Process
Regulation Of The Force Of Heart Contraction
Negative Regulation Of Cardiac Muscle Hypertrophy
Cell Redox Homeostasis
Oxidation-reduction Process
Carbohydrate Metabolic Process
Pathways
Drugs
Diseases
GWAS
HIV-1 susceptibility (
21160409
)
Protein-Protein Interactions
57 interactors:
ADAMTSL4
ALKBH3
BOLA1
CBLB
CGGBP1
CIAPIN1
EFEMP2
FAM118A
FRA10AC1
GMCL1
GRN
HEXDC
IKZF1
KRT31
KRT38
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP13-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
LCE2D
MAP3K3
MAPK6
MAPKBP1
MOXD1
NADK
NOTCH2NL
OLFM3
PCSK5
PFDN5
PLSCR1
PRKCQ
PRKCZ
PRKD2
RGS20
SOX7
STAU1
TCF4
TMEM25
TRAF1
TRIM36
TRIM42
UGP2
ZBTB44
ZNF148
ZNF426
ZNF512B
ZNF544
9 interactors:
ADPRHL2
C7orf25
EEF1D
GDPD2
GLRX3
PARK2
PSD
RILPL2
TUBB3
Entrez ID
10539
284004
HPRD ID
10153
08677
Ensembl ID
ENSG00000108010
ENSG00000169660
Uniprot IDs
O76003
Q8WVB3
PDB IDs
2DIY
2WZ9
2YAN
3ZYW
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Developmental Process
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Interleukin-4 Production
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Regulation Of Cell Activation
Regulation Of T Cell Activation
Cell Death
Death
Multicellular Organismal Development
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Anatomical Structure Development
Positive Regulation Of Neutrophil Differentiation
Renin Secretion Into Blood Stream
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cellular Process
Transcription, DNA-templated
Regulation Of T Cell Receptor Signaling Pathway
Embryonic Digestive Tract Development
Positive Regulation Of Immune System Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
RNA Biosynthetic Process
Regulation Of Lymphocyte Activation
Protein Kinase D Signaling
Positive Regulation Of T-helper 2 Cell Activation
Oxidative Single-stranded DNA Demethylation
Positive Regulation Of Interleukin-13 Secretion
Positive Regulation Of Interleukin-5 Secretion
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure
Platelet Activation
Regulation Of Insulin Receptor Signaling Pathway
Apoptotic Process
Positive Regulation Of T Cell Activation
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Mitochondrial Fusion
Positive Regulation Of Protein Linear Polyubiquitination
Dopamine Uptake Involved In Synaptic Transmission
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Dopamine
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Manganese Ion
Protein K27-linked Ubiquitination
Protein K29-linked Ubiquitination
Negative Regulation Of Mitochondrial Fusion
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitochondrial Fusion
Negative Regulation Of Glucokinase Activity
Neuron Cellular Homeostasis
Positive Regulation Of Oxidative Stress-induced Cell Death
Protein K6-linked Ubiquitination
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Mitochondrial Fission
Regulation Of Mitochondrion Degradation
Negative Regulation Of Cardiac Muscle Hypertrophy
Dopamine Transport
Negative Regulation Of Muscle Hypertrophy
Aggresome Assembly
Regulation Of Mitochondrial Fission
Neurotransmitter Uptake
Norepinephrine Metabolic Process
Negative Regulation Of Actin Filament Bundle Assembly
Synaptic Transmission, Dopaminergic
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Zinc Ion Homeostasis
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Response To Manganese Ion
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Cellular Response To Ammonium Ion
Cellular Response To Superoxide
Regulation Of Dopamine Secretion
Response To Oxidative Stress
Cellular Response To Toxic Substance
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Monoamine Transport
Mitochondrial Fission
Cellular Response To Catecholamine Stimulus
Negative Regulation Of Oxidative Stress-induced Cell Death
Response To Superoxide
Startle Response
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