GLRX3 and TCL1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLRX3	TCL1B
Description		glutaredoxin 3	TCL1 family AKT coactivator B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell Cortex Z Disc Dendrite Iron-sulfur Cluster Assembly Complex
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Intracellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis	Intracellular Signal Transduction
Pathways		Iron uptake and transport
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Refractive error ( 32231278)
Interacting Genes		99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CEBPA CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	17 interacting genes: AKT1 AKT2 APP BAG4 DRC8 GLRX3 LSM1 LSM5 LSM7 MARK1 MEIS3 MKRN3 PLEKHA3 PNMA1 SNRPG TNPO2 ZNF330
Entrez ID		10539	9623
HPRD ID		10153	04795
Ensembl ID		ENSG00000108010	ENSG00000213231
Uniprot IDs		A0A140VJK1 O76003	O95988
PDB IDs		2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Iron-sulfur Cluster Assembly Protein Binding Iron-sulfur Cluster Assembly Complex Identical Protein Binding	Lsm1-7-Pat1 Complex Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Ribonucleoprotein Complex Spliceosomal Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex U6 SnRNP RNA Splicing, Via Transesterification Reactions Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fibroblast Migration U2-type Prespliceosome Nucleus Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Polysaccharide Biosynthetic Process MRNA Catabolic Process Molecular Function Activator Activity U12-type Spliceosomal Complex Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Postsynapse Organization RNA Binding RNA Splicing Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Protein Localization To Plasma Membrane Regulation Of Fibroblast Migration Response To Nerve Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Glycogen Metabolic Process Cell Cortex Regulation Of TRNA Methylation
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