GLRX3 and PLEKHG4B

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		GLRX3	PLEKHG4B
Description		glutaredoxin 3	pleckstrin homology and RhoGEF domain containing G4B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell Cortex Z Disc Dendrite Iron-sulfur Cluster Assembly Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Basal Plasma Membrane Membrane Extrinsic Component Of Membrane Anchoring Junction
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Intracellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction Cell-cell Adhesion
Pathways		Iron uptake and transport	CDC42 GTPase cycle
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Asthma (childhood onset) ( 27611488) Face memory ( 31596458)
Interacting Genes		99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CEBPA CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	4 interacting genes: CDC42 FHL3 GLRX3 KPNA4
Entrez ID		10539	153478
HPRD ID		10153	13900
Ensembl ID		ENSG00000108010	ENSG00000153404
Uniprot IDs		A0A140VJK1 O76003	A0AAK2PKJ8 Q96PX9
PDB IDs		2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Iron-sulfur Cluster Assembly Protein Binding Iron-sulfur Cluster Assembly Complex Identical Protein Binding	Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Actin Filament-based Process Establishment Of Apical/basal Cell Polarity Positive Regulation Of Pinocytosis Dendritic Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Endothelin Receptor Signaling Pathway Involved In Heart Process Cardiac Conduction System Development Embryonic Heart Tube Development Focal Adhesion Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Dendritic Spine Morphogenesis Dendrite Establishment Of Golgi Localization Actin Cytoskeleton Organization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Z Disc Positive Regulation Of Hippo Signaling NLS-bearing Protein Import Into Nucleus Dopamine Secretion Catecholamine Secretion Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Dopamine Transport NLS-dependent Protein Nuclear Import Complex Iron-sulfur Cluster Assembly Complex Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Spindle Midzone Regulation Of The Force Of Heart Contraction
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