ARPC2 and ACTR3

Number of citations of the paper that reports this interaction (PMID 11721045)
137

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		ARPC2	ACTR3
Gene Name		actin related protein 2/3 complex, subunit 2, 34kDa	ARP3 actin-related protein 3 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Leading Edge Neuron Projection Synapse Extracellular Vesicular Exosome	Golgi Membrane Podosome Cytosol Actin Filament Arp2/3 Protein Complex Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Hemidesmosome Excitatory Synapse Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Kinesin Binding AP-1 Adaptor Complex Binding Actin Filament Binding Arp2/3 Complex Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Positive Regulation Of Lamellipodium Assembly Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Response To Carbohydrate Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Myosin II Filament Organization Innate Immune Response Response To Antibiotic Ephrin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Filopodium Assembly Spindle Localization Cilium Morphogenesis
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS	13 interactors: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN HCLS1 JUND WASF2 WASF3 WASL
Entrez ID		10109	10096
HPRD ID		10367	05024
Ensembl ID		ENSG00000163466	ENSG00000115091
Uniprot IDs		O15144 Q53R19	B4DXW1 P61158
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Nucleation Regulation Of Cellular Component Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Polymerization Regulation Of Protein Complex Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Projection Organization Immune Response-regulating Signaling Pathway Actin Polymerization Or Depolymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Protein Polymerization Chemotaxis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Protein Localization To Cell Leading Edge Spindle Assembly Involved In Female Meiosis I Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Meiotic Nuclear Division	Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Filament-based Process Cytoskeleton Organization Phagocytosis Cell Projection Organization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Development Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Cell Morphogenesis Cell Differentiation Positive Regulation Of Protein Polymerization Immune Response-regulating Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Actin Nucleation Regulation Of Immune System Process Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cellular Component Size Positive Regulation Of Protein Complex Assembly Neuron Development Positive Regulation Of Immune Response Neuron Projection Morphogenesis Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Actin Polymerization Or Depolymerization Neurogenesis
Tagcloud ?		10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative	actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Difference) ?		10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative	actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Intersection) ?