ARPC2 and ARPC1B

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (cross-linking study, biochemical)
HPRD (in vitro, in vivo)

		ARPC2	ARPC1B
Description		actin related protein 2/3 complex subunit 2	actin related protein 2/3 complex subunit 1B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Synaptic Vesicle Membrane Cell Leading Edge Site Of Double-strand Break Muscle Cell Projection Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Response To Estrogen
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 23128233 28067908) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 25096241 29403010)	Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		8 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B NFE2L2 SHANK3 WAS	11 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA CEBPA PAK1 SRPK2 WAS
Entrez ID		10109	10095
HPRD ID		10367	10366
Ensembl ID		ENSG00000163466	ENSG00000130429
Uniprot IDs		O15144 Q53R19	A4D275 O15143
PDB IDs		6UHC 6YW6 6YW7 8P94	6UHC 6YW6 8P94
Enriched GO Terms of Interacting Partners?		Actin Binding Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Actin Nucleation Regulation Of Lamellipodium Organization Supramolecular Fiber Organization Actin Filament Binding Actin Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Site Of Double-strand Break Structural Constituent Of Cytoskeleton Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytoskeleton Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cytosol Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Actin Polymerization Or Depolymerization Positive Regulation Of Glutathione Biosynthetic Process Regulation Of T Cell Antigen Processing And Presentation Tubulobulbar Complex Actin Filament Branching Regulation Of Smooth Muscle Cell Migration Cellular Response To Type II Interferon Negative Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Organization Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Negative Regulation Of Locomotion Regulation Of Glutathione Biosynthetic Process Regulation Of Proteolysis Positive Regulation Of Cell Projection Organization	Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Site Of Double-strand Break Actin Cytoskeleton Actin Filament Supramolecular Fiber Organization Actin Filament Organization Actin Filament Polymerization Cytoskeleton Regulation Of Lamellipodium Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Filament-based Process Focal Adhesion Lamellipodium Actin Polymerization Or Depolymerization Cell Projection Actin Filament Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Presynapse Positive Regulation Of DNA Recombination Protein Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Cytokine Regulation Of Actin Filament Organization Response To Peptide Positive Regulation Of Double-strand Break Repair Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Projection Organization Cellular Component Assembly Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Cytosol Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA Recombination Positive Regulation Of DNA Repair
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