CCT3 and SH3BP4

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		CCT3	SH3BP4
Gene Name		chaperonin containing TCP1, subunit 3 (gamma)	SH3-domain binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Plasma Membrane Cell Body Extracellular Vesicular Exosome	Nucleus Cytoplasm Coated Pit Clathrin-coated Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding	GDP-dissociation Inhibitor Activity Protein Binding Ras GTPase Binding Identical Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process Pore Complex Assembly 'de Novo' Posttranslational Protein Folding Toxin Transport	Endocytosis Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS		mean corpuscular hemoglobin concentration ( 20139978) Subcutaneous adipose tissue ( 22589738)	Dialysis-related mortality ( 21546767) Orofacial clefts ( 22419666)
Protein-Protein Interactions		13 interactors: EIF2B2 FANCA HNRNPA0 HSPA8 MAPK6 MIPOL1 PAFAH1B2 RAF1 SH3BP4 SSSCA1 VAV2 VHL XRCC6	21 interactors: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37
Entrez ID		7203	23677
HPRD ID		08969	09285
Ensembl ID		ENSG00000163468	ENSG00000130147
Uniprot IDs		B3KX11 P49368 Q59H77	Q9P0V3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Autophagy Nervous System Development Death-inducing Signaling Complex Assembly Negative Regulation Of Fibril Organization Anatomical Structure Development Response To Stimulus Response To Organic Substance Neurogenesis Axon Guidance Cellular Response To Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Posttranscriptional Regulation Of Gene Expression Female Gonad Development Cell Morphogenesis Response To Heat Development Of Primary Female Sexual Characteristics Cellular Hyperosmotic Salinity Response Regulation Of Fibril Organization Developmental Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Axonogenesis Regulation Of Metabolic Process Clathrin Coat Disassembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To X-ray Chemotaxis Defense Response Neuron Projection Morphogenesis Multicellular Organismal Development Establishment Of Integrated Proviral Latency Response To Temperature Stimulus Negative Regulation Of Cell Proliferation Platelet Activation Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Neurotrophin TRK Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Cellular Response To Stress Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway	Protein Folding Toxin Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Heat G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Binding Of Sperm To Zona Pellucida Protein Localization Substantia Nigra Development Response To Temperature Stimulus Sperm-egg Recognition Steroid Hormone Receptor Complex Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization 'de Novo' Protein Folding Cell-cell Recognition Cellular Response To Heat Negative Regulation Of Peptidyl-serine Dephosphorylation Cerebellum Structural Organization Regulation Of Heart Rate By Hormone Mitotic Cell Cycle Process Midbrain Development Positive Regulation Of DNA-dependent DNA Replication Initiation Mitotic Cell Cycle Regulation Of Mitochondrion Organization Cell Recognition Single Fertilization Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of DNA-dependent DNA Replication Initiation Cellular Response To Stress Maintenance Of Protein Location In Cell Regulation Of Cell Death
Tagcloud ?		adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Difference) ?		adequately cct5 cct7 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Intersection) ?