RPL5 and KRT31

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RPL5	KRT31
Description		ribosomal protein L5	keratin 31
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Keratinization Formation of the cornified envelope
Drugs
Diseases		Diamond-Blackfan anemia (DBA)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 17660530 19525955)	Brown vs. black hair color ( 30531825)
Interacting Genes		32 interacting genes: BCAS2 CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 FOXP1 HARS1 IPO13 IPO5 IPO7 KPNB1 KRT31 MAP3K14 MDM2 NVL OGT PDCD4 PDE4B PPM1D RNA5S7 RNF181 SAYSD1 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL	397 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AIRIM AKR7A3 ALDH3B1 ALG13 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BAG4 BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf216 C3 CA6 CARD9 CATIP CATSPER1 CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK13 CDK18 CDKN1A CDKN2C CDR2L CEP55 CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CFAP90 CFTR CHCHD2 CHRNG CIMIP4 CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CPSF7 CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DHX57 DMRT3 DOCK2 DTNB EIF4E2 EIF4ENIF1 EIF4G1 ENKD1 EPDR1 ESS2 EXOC8 EXOSC5 EXOSC7 FADS2 FAM110A FAM124B FAM50B FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GARIN6 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GRN GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HOXC8 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KANK2 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MAZ MID2 MOS MRPL40 MRPL44 MRPS11 MSRB3 MTA1 MXD3 MXI1 MYO15B MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 NXF1 OTUB2 OTX1 P2RX7 P3H3 PATL1 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPF6 PRPH PRR19 PRR3 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RBFOX2 RBM15 RBM22 RBM7 RCOR3 RHPN1 RIBC1 RPL5 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SAXO4 SCNM1 SEC14L4 SEMA4C SF1 SFPQ SHC3 SHFL SHISA6 SIRPA SLAIN1 SLC15A3 SLC23A1 SLC25A42 SLC25A6 SLIRP SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SNRPB SNRPC SNW1 SPATA24 SPATA31J1 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 SUV39H1 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TFAP2D THAP7 TIAL1 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TXNL4A TYK2 UACA UBASH3A UNKL USHBP1 USP2 UTP14A UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZC3H8 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZMAT5 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF648 ZNF688 ZNF69 ZNF835 ZNRF2P1
Entrez ID		6125	3881
HPRD ID		04699	03047
Ensembl ID		ENSG00000122406	ENSG00000094796
Uniprot IDs		A2RUM7 P46777	Q15323
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Protein Localization To Nucleus Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Localization Sequence Binding Cytosol Nuclear Pore Ribosomal Protein Import Into Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization To Organelle Regulation Of Signaling Negative Regulation Of Developmental Growth Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Nucleoplasm Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Proteolysis Negative Regulation Of Gene Expression Double-strand Break Repair Via Classical Nonhomologous End Joining Signal Transduction In Response To DNA Damage Small GTPase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Nucleolus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Intracellular Protein Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Protein Binding Keratinization Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Carbon Dioxide Transport Spliceosomal Complex MRNA Processing Cytoskeleton Nuclear Speck Positive Regulation Of Urine Volume MRNA Metabolic Process Nitric Oxide Transport Nucleus RNA Processing
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?