RPL5 and SAYSD1

Number of citations of the paper that reports this interaction (PubMedID 36848233)
56

Data Source:
BioGRID (pull down)

		RPL5	SAYSD1
Description		ribosomal protein L5	SAYSVFN motif domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity	UFM1-modified Protein Reader Activity
	Biological Process	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Rescue Of Stalled Ribosome
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases		Diamond-Blackfan anemia (DBA)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 17660530 19525955)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Protein C levels ( 28082259)
Interacting Genes		32 interacting genes: BCAS2 CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 FOXP1 HARS1 IPO13 IPO5 IPO7 KPNB1 KRT31 MAP3K14 MDM2 NVL OGT PDCD4 PDE4B PPM1D RNA5S7 RNF181 SAYSD1 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL	5 interacting genes: HSPA8 RPL26 RPL5 RPS2 UFM1
Entrez ID		6125	55776
HPRD ID		04699	12892
Ensembl ID		ENSG00000122406	ENSG00000112167
Uniprot IDs		A2RUM7 P46777	Q9NPB0
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Protein Localization To Nucleus Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Localization Sequence Binding Cytosol Nuclear Pore Ribosomal Protein Import Into Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization To Organelle Regulation Of Signaling Negative Regulation Of Developmental Growth Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Nucleoplasm Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Proteolysis Negative Regulation Of Gene Expression Double-strand Break Repair Via Classical Nonhomologous End Joining Signal Transduction In Response To DNA Damage Small GTPase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Nucleolus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Intracellular Protein Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Ribosomal Large Subunit Biogenesis Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Protein Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly RNA Binding Regulation Of Translation Involved In Cellular Response To UV Regulation Of Signal Transduction By P53 Class Mediator Lumenal Side Of Lysosomal Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Protein Import Extracellular Exosome Positive Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Biogenesis Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy RNA Processing C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Regulation Of Protein Ubiquitination RRNA Processing Negative Regulation Of Protein Neddylation Protein K69-linked Ufmylation ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification RRNA Metabolic Process Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Ufmylation Autophagy Ubiquitin Protein Ligase Binding 5S RRNA Binding Cadherin Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin Ligase Inhibitor Activity
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