RPL5 and CSNK2B

Number of citations of the paper that reports this interaction (PubMedID 9042965)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RPL5	CSNK2B
Description		ribosomal protein L5	casein kinase 2 beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PML Body PcG Protein Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity	Chromatin Binding Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Release From Viral Latency Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of SMAD Protein Signal Transduction Endothelial Tube Morphogenesis Protein-containing Complex Assembly Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Viral Life Cycle
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			ATP Quercetin
Diseases		Diamond-Blackfan anemia (DBA)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 17660530 19525955)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Systemic lupus erythematosus ( 26316170) Ulcerative colitis ( 28067908)
Interacting Genes		32 interacting genes: BCAS2 CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 FOXP1 HARS1 IPO13 IPO5 IPO7 KPNB1 KRT31 MAP3K14 MDM2 NVL OGT PDCD4 PDE4B PPM1D RNA5S7 RNF181 SAYSD1 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL	222 interacting genes: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BANP BCCIP BHLHE41 BID BMI1 BRCA1 BTF3 C6orf136 CACNA1A CALM1 CCDC187 CCNB1 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CHEK1 CHRNA4 CIC CIPC CLOCK COIL COL4A2 COPS3 COPS7A CPNE7 CREB1 CSN1S1 CSN2 CSNK1E CSNK2A1 CSNK2A2 CST1 CTDP1 CTNNB1 DACT1 DALRD3 DAXX DELEC1 DENND5A DNMT1 DPF3 DSCAM DUX1 DYNLT2B EIF2S2 EIF5 EIF6 EPS8 ERCC6 ERCC8 ESR1 FAF1 FAM86C1P FBXL15 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 FXR1 FXR2 GADD45GIP1 GAMT GBP2 GLB1 GLIS2 GNB5 GRIN2A GRIN2B GRK2 GSK3B HEXB HNRNPA2B1 HOXB5 HOXB6 HTRA1 HYPK IER3IP1 INO80B INTS11 IRS1 ITSN1 KDM6B KIF2C LCK LEPR LMO4 LRP5L LTB4R2 LYN LYST MAPK14 MBD4 MDM2 MME MOXD1 MPP2 NAP1L1 NCF1 NGDN NMT2 NOLC1 NOTCH3 NPAS2 NRBP1 NRF1 NTAQ1 ODC1 OGA OGT PDS5A PER1 PER2 PFKFB4 PHF11 PIMREG PIN1 PITPNA PLXNA3 POT1 PPID PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PTTG2 PYROXD2 RAD17 RAD51 RFC1 RNF126 RNF7 RORB RPA1 RPL13 RPL41 RPL5 RPS6KB1 RRAD RXRA SARNP SDHA SEC11A SELENOI SHMT1 SHMT2 SIMC1 SNX2 SPOUT1 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TENM1 TFAP2A TFAP2D TLE1 TLX3 TNFAIP1 TOP2B TP53 TP53BP2 TP63 TRIM54 TSEN54 TUBB2B TWF1 UBE2I UPF1 USO1 UTP14A VDAC1 VMA22 VRK3 WDR1 WDR18 WFIKKN1 WWOX ZNF19 ZNF410 ZNF44 ZNF71 ZNF784 ZNHIT1
Entrez ID		6125	1460
HPRD ID		04699	00278
Ensembl ID		ENSG00000122406	ENSG00000204435
Uniprot IDs		A2RUM7 P46777	A0A1U9X7J2 N0E4C7 P67870
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1 6Q38
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Protein Localization To Nucleus Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Localization Sequence Binding Cytosol Nuclear Pore Ribosomal Protein Import Into Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization To Organelle Regulation Of Signaling Negative Regulation Of Developmental Growth Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Nucleoplasm Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Proteolysis Negative Regulation Of Gene Expression Double-strand Break Repair Via Classical Nonhomologous End Joining Signal Transduction In Response To DNA Damage Small GTPase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Nucleolus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Intracellular Protein Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Cell Cycle Cytoplasm Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Response Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression Nucleic Acid Metabolic Process Circadian Rhythm Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Photoperiodism Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Response To Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cellular Response To Oxygen-containing Compound Cell Cycle Phase Transition Intracellular Signal Transduction
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