VEGFB and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VEGFB	KLHL12
Description		vascular endothelial growth factor B	kelch like family member 12
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	Degradation of DVL
Drugs		Aflibercept
Diseases		Gastric cancer
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		6 interacting genes: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		7423	59349
HPRD ID		03237	13925
Ensembl ID		ENSG00000173511	ENSG00000117153
Uniprot IDs		P49765 Q7LAP4	Q53G59 Q9H7R2
PDB IDs		2C7W 2VWE 2XAC 6TKK	2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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