VEGFB and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VEGFB	KLHL12
Gene Name		vascular endothelial growth factor B	kelch-like family member 12
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein O-linked Glycosylation Blood Coagulation Negative Regulation Of Gene Expression Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		7423	59349
HPRD ID		03237	13925
Ensembl ID			ENSG00000117153
Uniprot IDs		P49765 Q7LAP4	Q53G59
PDB IDs		2C7W 2VWE 2XAC	2VPJ
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Regulation Of MAPK Cascade Patterning Of Blood Vessels Sprouting Angiogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Artery Morphogenesis Regulation Of Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of MAPK Cascade Coronary Vasculature Morphogenesis Regulation Of Signal Transduction Regulation Of Phosphorylation Commissural Neuron Axon Guidance Regulation Of Signaling Coronary Vasculature Development Regulation Of Phosphorus Metabolic Process Cell Chemotaxis Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Involved In Sprouting Angiogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Chemotaxis Positive Regulation Of Intracellular Signal Transduction Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Growth Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		11q13 250bp 4kb caenorhabditis centromeric characterisation designated dnaj elegans encode greatest homolog hspf2 interrupted introns keratinocytes lies mcg18 message name neoplasia ovary searches sequenced shares similarity spanning undefined vrf
Tagcloud (Difference) ?		11q13 250bp 4kb caenorhabditis centromeric characterisation designated dnaj elegans encode greatest homolog hspf2 interrupted introns keratinocytes lies mcg18 message name neoplasia ovary searches sequenced shares similarity spanning undefined vrf
Tagcloud (Intersection) ?