VEGFB and FLT1

Number of citations of the paper that reports this interaction (PMID 9751730)
55

Data Source:
HPRD (in vivo)

		VEGFB	FLT1
Gene Name		vascular endothelial growth factor B	fms-related tyrosine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Receptor Complex
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Protein Heterodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding VEGF-A-activated Receptor Activity VEGF-B-activated Receptor Activity Placental Growth Factor-activated Receptor Activity Identical Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein O-linked Glycosylation Blood Coagulation Negative Regulation Of Gene Expression Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Patterning Of Blood Vessels Sprouting Angiogenesis Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Neurophilin interactions with VEGF and VEGFR
Drugs			Sorafenib Sunitinib Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib
Diseases
GWAS			Cognitive performance ( 19734545) Coronary heart disease ( 23364394)
Protein-Protein Interactions		6 interactors: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA	24 interactors: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		7423	2321
HPRD ID		03237	01297
Ensembl ID			ENSG00000102755
Uniprot IDs		P49765 Q7LAP4	L7RSL3 P17948
PDB IDs		2C7W 2VWE 2XAC	1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Regulation Of MAPK Cascade Patterning Of Blood Vessels Sprouting Angiogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Artery Morphogenesis Regulation Of Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of MAPK Cascade Coronary Vasculature Morphogenesis Regulation Of Signal Transduction Regulation Of Phosphorylation Commissural Neuron Axon Guidance Regulation Of Signaling Coronary Vasculature Development Regulation Of Phosphorus Metabolic Process Cell Chemotaxis Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Involved In Sprouting Angiogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Chemotaxis Positive Regulation Of Intracellular Signal Transduction Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Growth Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Signal Transduction Response To Organic Substance Regulation Of Intracellular Signal Transduction Locomotion Signaling Cell Communication Cellular Response To Peptide Hormone Stimulus Anatomical Structure Morphogenesis Cellular Response To Peptide Cell Migration Innate Immune Response Response To Stress Cell Motility Cell Development Regulation Of Signal Transduction Cellular Response To Stimulus Fc Receptor Signaling Pathway Blood Vessel Morphogenesis Cellular Response To Hormone Stimulus Cell Differentiation Immune Response Regulation Of Immune System Process Blood Coagulation Hemostasis Defense Response Positive Regulation Of MAPK Cascade Anatomical Structure Development Regulation Of MAPK Cascade Angiogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Neuron Differentiation Regulation Of Signaling Response To Peptide Immune System Process Cell Activation Blood Vessel Development Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Vasculature Development
Tagcloud ?		11q13 250bp 4kb caenorhabditis centromeric characterisation designated dnaj elegans encode greatest homolog hspf2 interrupted introns keratinocytes lies mcg18 message name neoplasia ovary searches sequenced shares similarity spanning undefined vrf	abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide
Tagcloud (Difference) ?		11q13 250bp 4kb caenorhabditis centromeric characterisation designated dnaj elegans encode greatest homolog hspf2 interrupted introns keratinocytes lies mcg18 message name neoplasia ovary searches sequenced shares similarity spanning undefined vrf	abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide
Tagcloud (Intersection) ?