BRSK2 and WEE1

Number of citations of the paper that reports this interaction (PMID 15150265)
11

Data Source:
HPRD (in vitro)

		BRSK2	WEE1
Gene Name		BR serine/threonine kinase 2	WEE1 G2 checkpoint kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Centrosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Tau-protein Kinase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Mitotic Nuclear Division Axonogenesis Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Actin Cytoskeleton Reorganization Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Mitotic Nuclear Division Blood Coagulation Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Cell Cycle
Pathways			G2/M DNA damage checkpoint G2/M Checkpoints G2/M Transition S Phase Cyclin E associated events during G1/S transition Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDC25B CDC25C VCP WEE1	21 interactors: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 FBXW11 NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		9024	7465
HPRD ID		11611	01907
Ensembl ID		ENSG00000174672	ENSG00000166483
Uniprot IDs		B3KVE9 B4DLY3 E9PLM7 Q8IWQ3	P30291 Q86V29
PDB IDs			1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Cell Cycle Peptidyl-tyrosine Dephosphorylation Cell Cycle Process Cellular Protein Modification Process Protein Dephosphorylation Regulation Of Cell Division Cell Cycle Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Deubiquitination Protein Hexamerization Cellular Protein Metabolic Process Aggresome Assembly Regulation Of Mitotic Cell Cycle Translesion Synthesis Regulation Of Cellular Protein Metabolic Process Dephosphorylation Female Meiosis I Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Protein Metabolic Process Postreplication Repair Regulation Of Catalytic Activity Oocyte Maturation Gamete Generation Regulation Of Protein Kinase Activity Female Meiotic Division Regulation Of Kinase Activity Sexual Reproduction Phosphate-containing Compound Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Oocyte Development Oocyte Differentiation Positive Regulation Of Protein Modification Process Organelle Organization Peptidyl-amino Acid Modification Regulation Of Cytokinesis Reproduction Cellular Response To Heat	G2/M Transition Of Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cellular Response To Stimulus Mitotic Cell Cycle Cell Communication Positive Regulation Of Intracellular Transport Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Cellular Protein Catabolic Process Signal Transduction Cellular Macromolecule Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Apoptotic Process Regulation Of Establishment Of Protein Localization Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Proteolysis Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		aicar ampk ampkbeta blunted brsk1 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Difference) ?		aicar ampk ampkbeta blunted brsk1 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Intersection) ?