USP1 and TRAF6

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP1	TRAF6
Description		ubiquitin specific peptidase 1	TNF receptor associated factor 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response DNA Damage Response Signal Transduction Canonical NF-kappaB Signal Transduction MRNA Transcription Animal Organ Morphogenesis Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Signaling Pathway Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Bone Remodeling Cell Development T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Protein K48-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Antiviral Innate Immune Response Intracellular Signaling Cassette Protein Branched Polyubiquitination Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1	184 interacting genes: ABL1 AKT1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FADD FAM177A1 FHL2 FYN GART GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK1 RIPK2 RIPK3 RNF114 RNF152 RNF31 RPL3 RPS2 RPS20 RPS27A RSAD2 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SUFU SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TTC3 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZDHHC11 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		7398	7189
HPRD ID		04593	03833
Ensembl ID		ENSG00000162607	ENSG00000175104
Uniprot IDs		O94782	Q9Y4K3
PDB IDs		6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L 8HZ2
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Defense Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Proteolysis Cytosol Activation Of Immune Response Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Polyubiquitination Positive Regulation Of Immune Response Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Defense Response Protein Kinase Activity MAPK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Signaling
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