USP1 and FANCD2

Number of citations of the paper that reports this interaction (PMID 15694335)
111

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		USP1	FANCD2
Gene Name		ubiquitin specific peptidase 1	Fanconi anemia, complementation group D2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Condensed Chromosome Nucleoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Protein Binding DNA Polymerase Binding
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	DNA Repair Synapsis Gamete Generation Response To Gamma Radiation
Pathways		Fanconi Anemia pathway Regulation of the Fanconi anemia pathway	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DTX3 FANCD2 PCNA PHF7 PHLPP1 TRAF6 TRIM46 UBB UBC	20 interactors: ATM ATR BLM BRCA1 BRCA2 FANCC FANCE FANCI FANCL MEN1 MRE11A NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB USP1
Entrez ID		7398	2177
HPRD ID		04593	01968
Ensembl ID		ENSG00000162607	ENSG00000144554
Uniprot IDs		O94782	Q9BXW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Viral Protein Processing Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Protein Ubiquitination Cellular Response To Growth Factor Stimulus Protein Polyubiquitination DNA Repair Response To Growth Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Notch Receptor Processing Response To Fibroblast Growth Factor Virion Assembly	Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Regulation Of DNA Replication Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle DNA Recombination Cell Cycle Process Response To Stress Double-strand Break Repair Negative Regulation Of DNA Replication Cell Cycle Checkpoint Response To Ionizing Radiation DNA Damage Checkpoint Telomere Maintenance DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Mitotic G2 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Process Chromosome Organization Regulation Of Response To DNA Damage Stimulus Mitotic Cell Cycle
Tagcloud ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?