USP1 and TAGLN

Number of citations of the paper that reports this interaction (PubMedID 37149635)
33

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, pull down)

		USP1	TAGLN
Description		ubiquitin specific peptidase 1	transgelin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Actin Binding Protein Binding
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis	Muscle Organ Development Epithelial Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs			Artenimol
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Apolipoprotein B levels ( 32203549) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Medication use (calcium channel blockers) ( 31015401) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1	9 interacting genes: ACD ACTA1 GORASP2 PIK3CD POT1 PRKCD RNF14 TINF2 USP1
Entrez ID		7398	6876
HPRD ID		04593	02891
Ensembl ID		ENSG00000162607	ENSG00000149591
Uniprot IDs		O94782	Q01995 Q5U0D2
PDB IDs		6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Positive Regulation Of DNA Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Error-prone Translesion Synthesis Positive Regulation Of DNA Strand Elongation Regulation Of Chromosome Organization Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Organelle Organization Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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