USP1 and BCAT2

Number of citations of the paper that reports this interaction (PubMedID 35663242)
48

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP1	BCAT2
Description		ubiquitin specific peptidase 1	branched chain amino acid transaminase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Catalytic Activity Branched-chain-amino-acid Transaminase Activity Protein Binding Transaminase Activity Transferase Activity L-leucine-2-oxoglutarate Transaminase Activity L-valine-2-oxoglutarate Transaminase Activity L-isoleucine-2-oxoglutarate Transaminase Activity
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis	Isoleucine Metabolic Process L-isoleucine Catabolic Process L-leucine Metabolic Process Valine Metabolic Process Lipid Metabolic Process Amino Acid Biosynthetic Process Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Regulation Of Hormone Levels Cellular Response To Leukemia Inhibitory Factor
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Branched-chain amino acid catabolism
Drugs			Pyridoxal phosphate Glutamic acid Leucine Isoleucine Pyridoxamine-5'-Phosphate N-[O-Phosphono-Pyridoxyl]-Isoleucine alpha-Ketoisovalerate
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Long-term memory (delayed word recall task) ( 29970928) Resting metabolic rate ( 28476931) Serum metabolite levels ( 33031748)
Interacting Genes		20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1	5 interacting genes: ALDOA APP CREB3 PTGDS USP1
Entrez ID		7398	587
HPRD ID		04593	00217
Ensembl ID		ENSG00000162607	ENSG00000105552
Uniprot IDs		O94782	B3KSI3 O15382
PDB IDs		6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW	1EKF 1EKP 1EKV 1KT8 1KTA 2A1H 2HDK 2HG8 2HGW 2HGX 2HHF 5BWR 5BWT 5BWU 5BWV 5BWW 5BWX 5CR5 5HNE 5I5S 5I5T 5I5U 5I5V 5I5W 5I5X 5I5Y 5I60 5MPR 6PRX
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex	Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Platelet Alpha Granule Lumen Protein Tetramerization Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Response To Stress Positive Regulation Of Error-prone Translesion Synthesis Positive Regulation Of Deacetylase Activity Cell Recognition Fructose-bisphosphate Aldolase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Protein Homooligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Chemotaxis Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Male Germ Cell Proliferation Release From Viral Latency
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