USP1 and NMRAL1

Number of citations of the paper that reports this interaction (PubMedID 31796584)
32

Data Source:
BioGRID (pull down, pull down)

		USP1	NMRAL1
Description		ubiquitin specific peptidase 1	NmrA like redox sensor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Urea cycle
Drugs			2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Erectile dysfunction ( 30583798) Schizophrenia ( 28991256) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1	5 interacting genes: FOXJ1 MECOM PCNA USP1 WDR48
Entrez ID		7398	57407
HPRD ID		04593	13678
Ensembl ID		ENSG00000162607	ENSG00000153406
Uniprot IDs		O94782	A0A384P622 Q9HBL8
PDB IDs		6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW	2EXX 2WM3 2WMD 3DXF 3E5M
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex	Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Macromolecule Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of DNA Metabolic Process PCNA Complex Regulation Of Cellular Response To Stress Replisome DNA Repair Regulation Of DNA Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Metabolic Process Response To UV Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding DNA Damage Response DNA Binding Metanephric Part Of Ureteric Bud Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Ciliary Basal Body Organization Tube Development Histone H3K9 Monomethyltransferase Activity Regulation Of Protein Monoubiquitination Regulation Of Primary Metabolic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Deubiquitinase Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K9me2 Methyltransferase Activity Developmental Process Regulation Of Germinal Center Formation
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