USP1 and WDR48

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		USP1	WDR48
Description		ubiquitin specific peptidase 1	WD repeat domain 48
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Late Endosome Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Deubiquitinase Activator Activity Ubiquitin Binding
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Single Fertilization Male Gonad Development Multicellular Organism Growth Skin Development Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Seminiferous Tubule Development Regulation Of Primary Metabolic Process Regulation Of Protein Monoubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1	7 interacting genes: NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC USP1
Entrez ID		7398	57599
HPRD ID		04593	11146
Ensembl ID		ENSG00000162607	ENSG00000114742
Uniprot IDs		O94782	A0A024R2L1 Q8TAF3
PDB IDs		6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW	5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ 7AY0 7AY1 7AY2 8A9J 8A9K 9EBS 9HNW
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex	Regulation Of DNA Metabolic Process Response To Radiation DNA Repair DNA Polymerase Binding Replication Fork Processing DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Repair Male Germ Cell Nucleus DNA Damage Response PCNA Complex Replisome Response To Glucoside Positive Regulation Of Error-prone Translesion Synthesis PCNA-p21 Complex Telomere Maintenance DNA Polymerase Processivity Factor Activity Regulation Of DNA Biosynthetic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Metabolic Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Spermatocyte Division Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Chorion Development Regulation Of Cellular Response To Stress Telomere Organization Positive Regulation Of DNA Repair Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of DNA Recombination Cellular Response To Cisplatin Response To Ionizing Radiation LncRNA Transcription Response To UV DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Camptothecin Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Radiation Nuclear Ubiquitin Ligase Complex Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Chromosome, Telomeric Region MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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