UGP2 and GLRX3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		UGP2	GLRX3
Gene Name		UDP-glucose pyrophosphorylase 2	glutaredoxin 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Cell Cortex Z Disc Extracellular Vesicular Exosome
	Molecular Function	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Glucose Binding Pyrimidine Ribonucleotide Binding Metal Ion Binding	Protein Kinase C Binding Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Poly(A) RNA Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Pathogenesis Glucose 1-phosphate Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation	Regulation Of The Force Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Cell Redox Homeostasis Oxidation-reduction Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Glucose metabolism Phase II conjugation Glycogen synthesis Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Glycogen storage diseases Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Metabolism of carbohydrates Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS			HIV-1 susceptibility ( 21160409)
Protein-Protein Interactions		5 interactors: ABCA1 ARIH2 CBS GLRX3 PCBP1	57 interactors: ADAMTSL4 ALKBH3 BOLA1 CBLB CGGBP1 CIAPIN1 EFEMP2 FAM118A FRA10AC1 GMCL1 GRN HEXDC IKZF1 KRT31 KRT38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE2D MAP3K3 MAPK6 MAPKBP1 MOXD1 NADK NOTCH2NL OLFM3 PCSK5 PFDN5 PLSCR1 PRKCQ PRKCZ PRKD2 RGS20 SOX7 STAU1 TCF4 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF148 ZNF426 ZNF512B ZNF544
Entrez ID		7360	10539
HPRD ID		08934	10153
Ensembl ID		ENSG00000169764	ENSG00000108010
Uniprot IDs		E7EUC7 Q16851	O76003
PDB IDs		3R2W 3R3I	2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Cysteine Biosynthetic Process From Serine Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process L-serine Catabolic Process Interleukin-1 Beta Secretion Hydrogen Sulfide Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Cysteine Metabolic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Homocysteine Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Phospholipid Efflux Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Hematopoietic Stem Cell Proliferation Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux L-serine Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cdc42 Protein Signal Transduction Regulation Of The Force Of Heart Contraction Protein K63-linked Ubiquitination	Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Positive Regulation Of Interleukin-4 Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Interleukin-4 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Activation Regulation Of T Cell Activation Cell Death Death Multicellular Organismal Development Positive Regulation Of Interleukin-2 Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Anatomical Structure Development Positive Regulation Of Neutrophil Differentiation Renin Secretion Into Blood Stream Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cellular Process Transcription, DNA-templated Regulation Of T Cell Receptor Signaling Pathway Embryonic Digestive Tract Development Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction RNA Biosynthetic Process Regulation Of Lymphocyte Activation Protein Kinase D Signaling Positive Regulation Of T-helper 2 Cell Activation Oxidative Single-stranded DNA Demethylation Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Positive Regulation Of T Cell Activation
Tagcloud ?		abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Difference) ?		abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Intersection) ?