UGP2 and PCBP1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UGP2	PCBP1
Gene Name		UDP-glucose pyrophosphorylase 2	poly(rC) binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Glucose Binding Pyrimidine Ribonucleotide Binding Metal Ion Binding	Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Pathogenesis Glucose 1-phosphate Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Glucose metabolism Phase II conjugation Glycogen synthesis Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Glycogen storage diseases Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Metabolism of carbohydrates Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ABCA1 ARIH2 CBS GLRX3 PCBP1	36 interactors: ANP32A APP CAV3 CELF2 CELF3 ERG EWSR1 GNB2 HMGA1 HNRNPD HNRNPK HNRNPLL LMNA MATR3 NOVA1 PABPC1 PCBP2 PCBP4 PDLIM7 PPIG PPIL3 PRPF3 PTBP1 PUF60 QKI RALY RBM11 RBM42 SNRPA SRSF3 TCERG1 TSC22D4 UGP2 ZCCHC10 ZNF384 ZNF830
Entrez ID		7360	5093
HPRD ID		08934	03128
Ensembl ID		ENSG00000169764	ENSG00000169564
Uniprot IDs		E7EUC7 Q16851	Q15365 Q53SS8
PDB IDs		3R2W 3R3I	1WVN 1ZTG 3VKE
Enriched GO Terms of Interacting Partners?		Cysteine Biosynthetic Process From Serine Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process L-serine Catabolic Process Interleukin-1 Beta Secretion Hydrogen Sulfide Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Cysteine Metabolic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Homocysteine Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Phospholipid Efflux Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Hematopoietic Stem Cell Proliferation Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux L-serine Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cdc42 Protein Signal Transduction Regulation Of The Force Of Heart Contraction Protein K63-linked Ubiquitination	MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Cell Aging Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Macromolecule Biosynthetic Process Negative Regulation Of Potassium Ion Transmembrane Transport MRNA 3'-end Processing RNA Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Ventricular Cardiac Muscle Cell Action Potential RNA 3'-end Processing Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Translation Cellular Process Cardiac Muscle Cell Action Potential Involved In Contraction Biosynthetic Process MRNA Polyadenylation Positive Regulation Of RNA Splicing Cardiac Muscle Cell Action Potential RNA Polyadenylation
Tagcloud ?		abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr	atypical au element encoding eta half knockdown markedly owing pigmentosum polh poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv
Tagcloud (Difference) ?		abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr	atypical au element encoding eta half knockdown markedly owing pigmentosum polh poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv
Tagcloud (Intersection) ?