UBE2A and UBA1

Number of citations of the paper that reports this interaction (PMID 17597759)
66

Data Source:
BioGRID (enzymatic study, pull down)

		UBE2A	UBA1
Gene Name		ubiquitin-conjugating enzyme E2A	ubiquitin-like modifier activating enzyme 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Cytoplasm Cytosol HULC Complex	Heterochromatin Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Modification-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Protein-Protein Interactions		20 interactors: CDK1 CDK2 CDK9 CDKN2A CRMP1 HIST2H2BE HLTF MDM2 PCNA RAD18 RNF20 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	39 interactors: BUB3 CDC34 CDK1 CREB3L1 CREB3L2 ECHS1 GAN GRB2 HGS HSPH1 MGMT PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2K UBE2L3 UBE2R2 UBE2S UBE2T UBE2W UBTD2
Entrez ID		7319	7317
HPRD ID		02422	02440
Ensembl ID		ENSG00000077721	ENSG00000130985
Uniprot IDs		P49459	P22314
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Arrest DNA Repair Chromosome Organization Regulation Of DNA Replication Chromatin Organization Protein Polyubiquitination Response To Stress Positive Regulation Of Cell Cycle Arrest Catabolic Process Cellular Protein Metabolic Process Ras Protein Signal Transduction Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Proteolysis Positive Regulation Of Cell Cycle Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cell Aging Organelle Organization Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Cellular Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint DNA Packaging Signal Transduction Involved In Cell Cycle Checkpoint	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteolysis Catabolic Process Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Protein Monoubiquitination Cellular Response To Stress Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Response To Organic Substance Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 3 Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Spindle Assembly Checkpoint
Tagcloud ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Difference) ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Intersection) ?