UBE2A and RNF20

Number of citations of the paper that reports this interaction (PMID 19410543)
102

Data Source:
BioGRID (enzymatic study)

		UBE2A	RNF20
Gene Name		ubiquitin-conjugating enzyme E2A	ring finger protein 20, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Cytoplasm Cytosol HULC Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	P53 Binding Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Protein-Protein Interactions		20 interactors: CDK1 CDK2 CDK9 CDKN2A CRMP1 HIST2H2BE HLTF MDM2 PCNA RAD18 RNF20 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	22 interactors: AMOTL2 ATM CDC73 HIST1H2BB HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HTT ITSN2 MSL1 PA2G4 PAF1 SMURF2 UBC UBE2A UBE2B UBE2E1 USHBP1 WAC ZDHHC17
Entrez ID		7319	56254
HPRD ID		02422	07410
Ensembl ID		ENSG00000077721	ENSG00000155827
Uniprot IDs		P49459	Q5VTR2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Arrest DNA Repair Chromosome Organization Regulation Of DNA Replication Chromatin Organization Protein Polyubiquitination Response To Stress Positive Regulation Of Cell Cycle Arrest Catabolic Process Cellular Protein Metabolic Process Ras Protein Signal Transduction Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Proteolysis Positive Regulation Of Cell Cycle Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cell Aging Organelle Organization Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Cellular Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint DNA Packaging Signal Transduction Involved In Cell Cycle Checkpoint	Histone Ubiquitination Chromatin Organization Histone Modification Histone H2B Ubiquitination Chromosome Organization Protein Monoubiquitination Chromatin Modification Histone Monoubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Transcription, DNA-templated Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Chromatin Silencing Protein K48-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Cell Cycle Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process G1 DNA Damage Checkpoint Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Histone H2A Ubiquitination Positive Regulation Of MRNA 3'-end Processing Chromatin Silencing At RDNA
Tagcloud ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Difference) ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Intersection) ?