UBE2A and ZMYM2

Number of citations of the paper that reports this interaction (PMID 12776193)
8

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		UBE2A	ZMYM2
Gene Name		ubiquitin-conjugating enzyme E2A	zinc finger, MYM-type 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Cytoplasm Cytosol HULC Complex	Cytosol PML Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Protein-Protein Interactions		20 interactors: CDK1 CDK2 CDK9 CDKN2A CRMP1 HIST2H2BE HLTF MDM2 PCNA RAD18 RNF20 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	20 interactors: CEBPE CREB1 FUS HNRNPA2B1 HNRNPH3 PTBP1 RCOR1 SFPQ SKIL SMAD3 SMAD4 SNIP1 SREBF2 SUMO1 SUMO2 UBE2A UBE2I UBTF ZBTB3 ZNF512B
Entrez ID		7319	7750
HPRD ID		02422	03745
Ensembl ID		ENSG00000077721	ENSG00000121741
Uniprot IDs		P49459	Q9UBW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Arrest DNA Repair Chromosome Organization Regulation Of DNA Replication Chromatin Organization Protein Polyubiquitination Response To Stress Positive Regulation Of Cell Cycle Arrest Catabolic Process Cellular Protein Metabolic Process Ras Protein Signal Transduction Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Proteolysis Positive Regulation Of Cell Cycle Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cell Aging Organelle Organization Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Cellular Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint DNA Packaging Signal Transduction Involved In Cell Cycle Checkpoint	Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Processing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Protein Sumoylation RNA Splicing, Via Transesterification Reactions Transcription From RNA Polymerase II Promoter RNA Splicing SMAD Protein Complex Assembly Metabolic Process MRNA Processing Regulation Of Transforming Growth Factor Beta2 Production DNA-templated Transcription, Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Production Of MiRNAs Involved In Gene Silencing By MiRNA Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Protein Catabolic Process Lens Fiber Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Tagcloud ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	advanced aggressive cassette challengeable effectively find finger formerly hairpin hcc hepatocellular immunohistochemical intensities library limitations malignancy regions relating reports responsiveness screens sequenced sorafenib stronger successful successive treat zinc
Tagcloud (Difference) ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring	advanced aggressive cassette challengeable effectively find finger formerly hairpin hcc hepatocellular immunohistochemical intensities library limitations malignancy regions relating reports responsiveness screens sequenced sorafenib stronger successful successive treat zinc
Tagcloud (Intersection) ?