UBE2A and H2BC3

Number of citations of the paper that reports this interaction (PubMedID 35938192)
50

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology)

		UBE2A	H2BC3
Description		ubiquitin conjugating enzyme E2 A	H2B clustered histone 3
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Lysosome Endosome Late Endosome Cytosol HULC Complex	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cytoplasmic Translation DNA Repair Postreplication Repair Chromatin Organization Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To UV Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Mitophagy	Nucleosome Assembly
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Interacting Genes		32 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 H2BC3 HECTD3 HLTF KCMF1 MDM2 PCNA PRKN PSMG1 RAD18 RC3H1 RNF167 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBA6 UBC UBR1 UBR3 UBR5 ZMYM2	49 interacting genes: AKT1 ANAPC11 APP BAP1 BARD1 BMI1 BRCA1 CDC20 CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 HUWE1 KAT2A KAT2B KMT2A KMT2C KMT2D MYB PALB2 PIAS1 PSMD4 PTPN6 RHBDD2 RNF168 RNF2 RNF20 RNF40 RNF8 RPS6KA5 SMYD5 TSPYL5 UBE2A UBR7 UHRF1 USP16 USP2 USP21 USP22 USP36 USP43 USP51 USP7
Entrez ID		7319	3018
HPRD ID		02422	07536
Ensembl ID		ENSG00000077721	ENSG00000276410
Uniprot IDs		A0A0D9SG71 P49459	P33778
PDB IDs		6CYO 6CYR 8BTL 8IEJ	3X1S 3X1U 9C62 9FGQ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Cellular Response To Stress Macromolecule Catabolic Process Transferase Activity DNA Damage Response Proteolysis Catabolic Process Chromatin Organization Protein K63-linked Ubiquitination Macromolecule Metabolic Process Response To Stress Nucleoplasm PML Body Zinc Ion Binding Ubiquitin Protein Ligase Binding Chromatin Remodeling Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Nucleus DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Hydrogen Peroxide Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription P53 Binding Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Activity Cellular Response To Actinomycin D Ubiquitin Activating Enzyme Activity Negative Regulation Of DNA-templated Transcription	Chromatin Remodeling Chromatin Organization Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Metabolic Process Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Protein Deubiquitination DNA Repair Chromatin Binding Protein Modification By Small Protein Removal DNA Damage Response Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Nucleus DNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Radiation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cysteine-type Deubiquitinase Activity Negative Regulation Of Biosynthetic Process Protein Ubiquitination Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
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