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UBE2A and UBR3
Number of citations of the paper that reports this interaction (PubMedID
25582440
)
50
Data Source:
BioGRID
(affinity chromatography technology, two hybrid, affinity chromatography technology)
UBE2A
UBR3
Description
ubiquitin conjugating enzyme E2 A
ubiquitin protein ligase E3 component n-recognin 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Lysosome
Endosome
Late Endosome
Cytosol
HULC Complex
Ubiquitin Ligase Complex
Cytoplasm
Membrane
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Cytoplasmic Translation
DNA Repair
Postreplication Repair
Chromatin Organization
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Response To UV
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Mitophagy
In Utero Embryonic Development
Suckling Behavior
Ubiquitin-dependent Protein Catabolic Process
Sensory Perception Of Smell
Embryo Development Ending In Birth Or Egg Hatching
Protein Ubiquitination
Olfactory Behavior
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Brain connectivity (
23471985
)
Longitudinal change in brain amyloid plaque burden (
26268530
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Urate levels in obese individuals (
25811787
)
Interacting Genes
32 interacting genes:
CBX5
CDK1
CDK2
CDK9
CDKN2A
CRMP1
EEF1D
H2BC21
H2BC3
HECTD3
HLTF
KCMF1
MDM2
PCNA
PRKN
PSMG1
RAD18
RC3H1
RNF167
RNF20
RNF4
RNF40
SDCBP
TP53
TRIM27
UBA1
UBA6
UBC
UBR1
UBR3
UBR5
ZMYM2
7 interacting genes:
APEX1
DZIP3
MAGEC2
UBE2A
UBE2B
UBE2D2
UBE2H
Entrez ID
7319
130507
HPRD ID
02422
15887
Ensembl ID
ENSG00000077721
ENSG00000144357
Uniprot IDs
A0A0D9SG71
P49459
Q6ZT12
PDB IDs
6CYO
6CYR
8BTL
8IEJ
Enriched GO Terms of Interacting Partners
?
Post-translational Protein Modification
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Activity
Protein Modification Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Cellular Response To Stress
Macromolecule Catabolic Process
Transferase Activity
DNA Damage Response
Proteolysis
Catabolic Process
Chromatin Organization
Protein K63-linked Ubiquitination
Macromolecule Metabolic Process
Response To Stress
Nucleoplasm
PML Body
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Chromatin Remodeling
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Response To Oxidative Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K29-linked Ubiquitination
Ubiquitin Ligase Complex
Regulation Of Transcription By RNA Polymerase II
Proteasomal Protein Catabolic Process
Nucleus
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
SUMO Transferase Activity
Positive Regulation Of Metabolic Process
Cellular Response To Hydrogen Peroxide
Protein Autoubiquitination
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
P53 Binding
Regulation Of RNA Biosynthetic Process
Cyclin-dependent Protein Kinase Activity
Cellular Response To Actinomycin D
Ubiquitin Activating Enzyme Activity
Negative Regulation Of DNA-templated Transcription
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Macromolecule Catabolic Process
HULC Complex
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-like Protein Transferase Activity
Catabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Postreplication Repair
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Modification Process
Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands
Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Telomere Maintenance Via Base-excision Repair
Transferase Activity
Protein Autoubiquitination
Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
DNA-(abasic Site) Binding
Double-stranded DNA Exodeoxyribonuclease Activity
Deoxyribonuclease (pyrimidine Dimer) Activity
Macromolecule Metabolic Process
Positive Regulation Of Reciprocal Meiotic Recombination
Proteasomal Protein Catabolic Process
Proteolysis
DNA Repair
Uracil DNA N-glycosylase Activity
Phosphodiesterase I Activity
ATP Binding
Response To UV
Double-stranded DNA 3'-5' DNA Exonuclease Activity
Chiasma Assembly
RNA-DNA Hybrid Ribonuclease Activity
BBSome
DNA Metabolic Process
Meiotic Telomere Clustering
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Double-stranded Telomeric DNA Binding
Telomere Localization
DNA Damage Response
3'-5'-DNA Exonuclease Activity
Nucleotide Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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