UBE2A and UBR3

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		UBE2A	UBR3
Gene Name		ubiquitin-conjugating enzyme E2A	ubiquitin protein ligase E3 component n-recognin 3 (putative)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Cytoplasm Cytosol HULC Complex	Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Protein Ubiquitination Olfactory Behavior
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Protein-Protein Interactions		20 interactors: CDK1 CDK2 CDK9 CDKN2A CRMP1 HIST2H2BE HLTF MDM2 PCNA RAD18 RNF20 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	4 interactors: DZIP3 UBC UBE2A UBE2B
Entrez ID		7319	130507
HPRD ID		02422	15887
Ensembl ID		ENSG00000077721	ENSG00000144357
Uniprot IDs		P49459	Q6ZT12
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Arrest DNA Repair Chromosome Organization Regulation Of DNA Replication Chromatin Organization Protein Polyubiquitination Response To Stress Positive Regulation Of Cell Cycle Arrest Catabolic Process Cellular Protein Metabolic Process Ras Protein Signal Transduction Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Proteolysis Positive Regulation Of Cell Cycle Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cell Aging Organelle Organization Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Cellular Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint DNA Packaging Signal Transduction Involved In Cell Cycle Checkpoint	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Ubiquitination Postreplication Repair Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Histone Ubiquitination Protein K48-linked Ubiquitination Protein Autoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process DNA Repair Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Response To UV Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Metabolic Process Cellular Protein Modification Process Response To Abiotic Stimulus Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell Cycle Antigen Processing And Presentation Response To Hypoxia Positive Regulation Of Meiosis I Cellular Response To Stress Proteolysis Cellular Protein Metabolic Process Response To Light Stimulus Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Histone Modification Catabolic Process Sperm Axoneme Assembly Viral Protein Processing Response To Radiation Regulation Of Cell Cycle Process In Utero Embryonic Development Protein Metabolic Process Positive Regulation Of Meiotic Nuclear Division Chromatin Modification
Tagcloud ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring
Tagcloud (Difference) ?		11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring
Tagcloud (Intersection) ?