H2BC3 and USP43

Number of citations of the paper that reports this interaction (PubMedID 30135474)
59

Data Source:
BioGRID (enzymatic study)

		H2BC3	USP43
Description		H2B clustered histone 3	ubiquitin specific peptidase 43
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Chromosome Cytosol	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity ISG15-specific Peptidase Activity
	Biological Process	Nucleosome Assembly	Proteolysis Protein Deubiquitination Translesion Synthesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Termination of translesion DNA synthesis
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		49 interacting genes: AKT1 ANAPC11 APP BAP1 BARD1 BMI1 BRCA1 CDC20 CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 HUWE1 KAT2A KAT2B KMT2A KMT2C KMT2D MYB PALB2 PIAS1 PSMD4 PTPN6 RHBDD2 RNF168 RNF2 RNF20 RNF40 RNF8 RPS6KA5 SMYD5 TSPYL5 UBE2A UBR7 UHRF1 USP16 USP2 USP21 USP22 USP36 USP43 USP51 USP7	3 interacting genes: H2BC3 HDAC1 YWHAE
Entrez ID		3018	124739
HPRD ID		07536	18926
Ensembl ID		ENSG00000276410	ENSG00000154914
Uniprot IDs		P33778	Q70EL4
PDB IDs		3X1S 3X1U 9C62 9FGQ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Metabolic Process Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Protein Deubiquitination DNA Repair Chromatin Binding Protein Modification By Small Protein Removal DNA Damage Response Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Nucleus DNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Radiation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cysteine-type Deubiquitinase Activity Negative Regulation Of Biosynthetic Process Protein Ubiquitination Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription	Hair Follicle Placode Formation Krueppel-associated Box Domain Binding Histone Deacetylase Binding Hippocampus Development Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Protein Domain Specific Binding Regulation Of Heart Rate By Hormone Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Heterodimerization Activity Negative Regulation Of Myotube Differentiation Enzyme Binding Host-mediated Suppression Of Viral Transcription Histone Deacetylase Activity Eyelid Development In Camera-type Eye Sin3-type Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation NuRD Complex Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Oligodendrocyte Differentiation Membrane Repolarization During Action Potential Protein Localization To Endoplasmic Reticulum Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Calcium Channel Inhibitor Activity Intracellular Potassium Ion Homeostasis Centrosome Separation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?