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H2BC3 and UHRF1
Number of citations of the paper that reports this interaction (PubMedID
14993289
)
59
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
H2BC3
UHRF1
Description
H2B clustered histone 3
ubiquitin like with PHD and ring finger domains 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Chromosome
Cytosol
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Replication Fork
Spindle
Nuclear Matrix
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Cis-regulatory Region Sequence-specific DNA Binding
Nucleic Acid Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Methyl-CpG Binding
Transferase Activity
Histone Binding
Identical Protein Binding
Hemi-methylated DNA-binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Histone H3K9me2/3 Reader Activity
DNA Damage Sensor Activity
Histone H3 Ubiquitin Ligase Activity
Biological Process
Nucleosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Response To Stress
DNA Damage Response
Protein Ubiquitination
Heterochromatin Formation
Homologous Recombination
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Protein Autoubiquitination
Mitotic Spindle Assembly
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
DNA methylation
Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Hip circumference adjusted for BMI (
34021172
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Mental health study participation (completed survey) (
31263887
)
Systolic blood pressure (
30578418
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
49 interacting genes:
AKT1
ANAPC11
APP
BAP1
BARD1
BMI1
BRCA1
CDC20
CDK1
CDK2
CHD4
CREBBP
DNMT1
DYRK1A
EID1
EP300
ERCC6
FANCD2
HUWE1
KAT2A
KAT2B
KMT2A
KMT2C
KMT2D
MYB
PALB2
PIAS1
PSMD4
PTPN6
RHBDD2
RNF168
RNF2
RNF20
RNF40
RNF8
RPS6KA5
SMYD5
TSPYL5
UBE2A
UBR7
UHRF1
USP16
USP2
USP21
USP22
USP36
USP43
USP51
USP7
36 interacting genes:
AKT1
ATR
DNMT3A
ERCC1
ERG
FANCD2
FZR1
H2AC4
H2BC3
H3-3A
H3-4
H3C1
H3C13
H3C14
H3C15
H4C14
KAT5
KIF11
LASP1
LIG1
MBD4
MUS81
NR3C1
PCLAF
PCNA
PLK1
PRKACA
SAP30
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2N
UHRF2
USP7
Entrez ID
3018
29128
HPRD ID
07536
06992
Ensembl ID
ENSG00000276410
ENSG00000276043
Uniprot IDs
P33778
A0A087WVR3
Q96T88
PDB IDs
3X1S
3X1U
9C62
9FGQ
2FAZ
2L3R
2LGG
2LGK
2LGL
2PB7
3ASK
3ASL
3BI7
3CLZ
3DB3
3DB4
3DWH
3FL2
3SHB
3SOU
3SOW
3SOX
3T6R
3ZVY
3ZVZ
4GY5
4QQD
5C6D
5IAY
5XPI
5YY9
5YYA
6B9M
6IIW
6VCS
6VED
6VYJ
6W92
7FB7
8JIG
8WMS
8XV4
8XV6
8XV7
8XV8
Enriched GO Terms of Interacting Partners
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Chromatin Remodeling
Chromatin Organization
Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Metabolic Process
Macromolecule Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Deubiquitination
DNA Repair
Chromatin Binding
Protein Modification By Small Protein Removal
DNA Damage Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Transferase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Proteolysis
Nucleus
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Radiation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Modification By Small Protein Conjugation
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Transcription Coactivator Activity
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Double-strand Break Repair
Regulation Of DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Nucleoplasm
Nucleus
DNA Repair
Nucleosome
Chromosome
Structural Constituent Of Chromatin
Chromatin Organization
Chromatin Remodeling
DNA Metabolic Process
DNA Damage Response
DNA Binding
Nucleosome Assembly
Nucleosome Organization
Cellular Response To Stress
Chromosome Organization
Protein Heterodimerization Activity
Chromosome, Telomeric Region
Protein-DNA Complex Assembly
Macromolecule Metabolic Process
Telomere Organization
Negative Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleic Acid Metabolic Process
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
TORC1 Signaling
Response To Radiation
Negative Regulation Of TORC1 Signaling
Protein-containing Complex
Mitotic DNA Damage Checkpoint Signaling
Protein Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic DNA Integrity Checkpoint Signaling
Chromatin Binding
Response To Ionizing Radiation
Regulation Of DNA Metabolic Process
Regulation Of Chromosome Organization
Ubiquitin Conjugating Enzyme Activity
Response To UV
TOR Signaling
Cellular Response To Nutrient Levels
Regulation Of Cell Cycle
Protein Modification By Small Protein Conjugation
Regulation Of Cellular Response To Stress
Negative Regulation Of TOR Signaling
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Tagcloud (Difference)
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Tagcloud (Intersection)
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