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HIST1H2BB and DYRK1A
Number of citations of the paper that reports this interaction (PMID
10644696
)
49
Data Source:
BioGRID
(enzymatic study)
HIST1H2BB
DYRK1A
Gene Name
histone cluster 1, H2bb
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Nucleoplasm
Nucleus
Nucleoplasm
Nuclear Speck
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Self-association
Tau Protein Binding
Biological Process
Chromatin Organization
Nucleosome Assembly
Mitotic Cell Cycle
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Autophosphorylation
Positive Regulation Of Protein Deacetylation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
Chromatin organization
HDACs deacetylate histones
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
G0 and Early G1
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
HIV-1 replication (
21364930
)
Metabolic syndrome (
20694148
)
Protein-Protein Interactions
12 interactors:
APP
CDK1
CDK2
CREBBP
DYRK1A
EID1
EP300
ERCC6
KAT2B
RNF20
UHRF1
USP16
26 interactors:
AMPH
APP
CCNL2
CLASRP
CREB1
FOXO1
GLI1
HIST1H2BB
HIST1H3A
HIST1H4A
LATS2
LIN52
LZTS2
PHYHIP
PRD
RB1
RBL1
SF3B1
SNCA
SRSF1
SRSF4
SRSF5
TROAP
YWHAB
YWHAE
YWHAG
Entrez ID
3018
1859
HPRD ID
07536
09018
Ensembl ID
ENSG00000196226
ENSG00000157540
Uniprot IDs
P33778
F8WAP0
Q13627
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
Enriched GO Terms of Interacting Partners
?
Histone Modification
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Modification
Positive Regulation Of Gene Expression
N-terminal Peptidyl-lysine Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Chromatin Organization
Positive Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Chromosome Organization
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
N-terminal Protein Amino Acid Acetylation
Cell Cycle
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Protein Modification Process
N-terminal Protein Amino Acid Modification
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Notch Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Protein Metabolic Process
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Protein Catabolic Process
Rhythmic Process
Nitrogen Compound Metabolic Process
Protein Metabolic Process
Mitotic Cell Cycle
Histone Acetylation
G2/M Transition Of Mitotic Cell Cycle
Internal Peptidyl-lysine Acetylation
Gene Expression
Negative Regulation Of Cellular Metabolic Process
Mitotic Cell Cycle
Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Processing
MRNA 3'-end Processing
Cellular Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Establishment Of Localization In Cell
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Hippo Signaling
Regulation Of Phosphorylation
Cellular Nitrogen Compound Metabolic Process
MRNA Processing
Negative Regulation Of Gene Expression
RNA 3'-end Processing
RNA Metabolic Process
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Nuclear Export
Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Termination Of RNA Polymerase II Transcription
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Dephosphorylation
MRNA Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Transcription From RNA Polymerase II Promoter
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Protein Metabolic Process
RNA Splicing
Response To Growth Factor
Positive Regulation Of Mitochondrion Organization
Regulation Of Cell Cycle
Regulation Of Protein Metabolic Process
Cellular Macromolecular Complex Assembly
DNA Replication-dependent Nucleosome Assembly
Cellular Response To Fibroblast Growth Factor Stimulus
Negative Regulation Of Biosynthetic Process
Apoptotic Process
Cell Cycle
Negative Regulation Of Wnt Signaling Pathway
Tagcloud
?
abolished
aimed
alteration
caused
colony
direct
explore
finding
fluorescent
hcc
hepatocellular
hepg2
mir
modulated
nfat
nfib
oncogene
overexpression
p53
propose
regulated
reporter
suggests
suppresses
syndrome
target
targeting
tumorigenesis
wild
Tagcloud (Difference)
?
abolished
aimed
alteration
caused
colony
direct
explore
finding
fluorescent
hcc
hepatocellular
hepg2
mir
modulated
nfat
nfib
oncogene
overexpression
p53
propose
regulated
reporter
suggests
suppresses
syndrome
target
targeting
tumorigenesis
wild
Tagcloud (Intersection)
?