H2BC3 and BMI1

Number of citations of the paper that reports this interaction (PubMedID 34316702)
124

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology)

		H2BC3	BMI1
Description		H2B clustered histone 3	BMI1 proto-oncogene, polycomb ring finger
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Chromosome Cytosol	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding
	Biological Process	Nucleosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Kidney Development Apoptotic Signaling Pathway Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases			Penile cancer
GWAS			Prostate-specific antigen levels ( 28139693)
Interacting Genes		49 interacting genes: AKT1 ANAPC11 APP BAP1 BARD1 BMI1 BRCA1 CDC20 CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 HUWE1 KAT2A KAT2B KMT2A KMT2C KMT2D MYB PALB2 PIAS1 PSMD4 PTPN6 RHBDD2 RNF168 RNF2 RNF20 RNF40 RNF8 RPS6KA5 SMYD5 TSPYL5 UBE2A UBR7 UHRF1 USP16 USP2 USP21 USP22 USP36 USP43 USP51 USP7	45 interacting genes: CASC9 CBX8 CEP126 CSNK2B DEFA5 E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H2BC3 H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RBM22 RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16
Entrez ID		3018	648
HPRD ID		07536	01277
Ensembl ID		ENSG00000276410	ENSG00000168283
Uniprot IDs		P33778	P35226
PDB IDs		3X1S 3X1U 9C62 9FGQ	2H0D 2NA1 3RPG 4R8P 5FR6 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Metabolic Process Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Protein Deubiquitination DNA Repair Chromatin Binding Protein Modification By Small Protein Removal DNA Damage Response Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Nucleus DNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Radiation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cysteine-type Deubiquitinase Activity Negative Regulation Of Biosynthetic Process Protein Ubiquitination Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription	PcG Protein Complex PRC1 Complex Chromatin Remodeling Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Structural Constituent Of Chromatin Chromosome Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Protein Modification Process Nucleoplasm Sex Chromatin Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Chromatin Binding Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Heterochromatin Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MLL1 Complex Developmental Process Involved In Reproduction Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II PML Body Protein Metabolic Process Ubiquitin-protein Transferase Activator Activity Protein Heterodimerization Activity Zinc Ion Binding Nuclear Body Response To Ionizing Radiation Signal Transduction In Response To DNA Damage
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