HIST1H2BB and ERCC6

Number of citations of the paper that reports this interaction (PMID 11003660)
80

Data Source:
BioGRID (far western blotting)

		HIST1H2BB	ERCC6
Gene Name		histone cluster 1, H2bb	excision repair cross-complementation group 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein Complex Binding Protein N-terminus Binding
	Biological Process	Chromatin Organization Nucleosome Assembly	Response To Superoxide DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Nucleotide Excision Repair RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription-coupled NER (TC-NER) RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 KAT2B RNF20 UHRF1 USP16	15 interactors: BRCA1 CHEK2 ERCC5 ERCC8 GTF2E2 HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A PARP1 POLR2A RNF11 TP53 XAB2 XPA
Entrez ID		3018	2074
HPRD ID		07536	00596
Ensembl ID		ENSG00000196226	ENSG00000225830
Uniprot IDs		P33778	Q03468 Q59FF6 Q8N328
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Modification Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Acetylation Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Rhythmic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Mitotic Cell Cycle Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation	DNA Metabolic Process DNA Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To UV Chromatin Assembly Response To Ionizing Radiation Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly Protein Autoubiquitination DNA Packaging Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Response To Stress DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Signal Transduction In Response To DNA Damage DNA Methylation On Cytosine DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Abiotic Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription Chromatin Silencing At RDNA Response To Light Stimulus Replicative Senescence Apoptotic Signaling Pathway Nucleosome Assembly Nucleotide-excision Repair, DNA Damage Removal Nucleosome Organization Negative Regulation Of Biosynthetic Process DNA Damage Checkpoint Response To Oxidative Stress Cellular Macromolecule Catabolic Process Response To X-ray Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing Positive Regulation Of DNA Repair Regulation Of Gene Expression, Epigenetic Chromosome Organization Protein Complex Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process DNA-templated Transcription, Initiation
Tagcloud ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Difference) ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Intersection) ?