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H2BC3 and PSMD4
Number of citations of the paper that reports this interaction (PubMedID
28988533
)
0
Data Source:
BioGRID
(pull down)
H2BC3
PSMD4
Description
H2B clustered histone 3
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Chromosome
Cytosol
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
RNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Molecular Adaptor Activity
Biological Process
Nucleosome Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Proteasome assembly
Proteasome assembly
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
49 interacting genes:
AKT1
ANAPC11
APP
BAP1
BARD1
BMI1
BRCA1
CDC20
CDK1
CDK2
CHD4
CREBBP
DNMT1
DYRK1A
EID1
EP300
ERCC6
FANCD2
HUWE1
KAT2A
KAT2B
KMT2A
KMT2C
KMT2D
MYB
PALB2
PIAS1
PSMD4
PTPN6
RHBDD2
RNF168
RNF2
RNF20
RNF40
RNF8
RPS6KA5
SMYD5
TSPYL5
UBE2A
UBR7
UHRF1
USP16
USP2
USP21
USP22
USP36
USP43
USP51
USP7
46 interacting genes:
ADRM1
APP
BTRC
CCNA2
CFTR
CUL1
EGFR
FBXO25
FLOT1
GNB5
H2AC4
H2BC3
ID1
MAP3K1
MDM2
MYOD1
NEDD4
NEDD4L
NEDD8
NUB1
OGT
PRKN
PTEN
RAD23A
RAD23B
RASSF8
RBCK1
RBM11
SCHIP1
SIAH2
SMURF1
SREBF2
STUB1
TCF3
TCP11L1
TMEM129
TP53
TRIM63
UBB
UBC
UBD
UBE2C
UBQLN1
UBQLN2
WWP2
XPC
Entrez ID
3018
5710
HPRD ID
07536
03386
Ensembl ID
ENSG00000276410
ENSG00000159352
Uniprot IDs
P33778
P55036
Q5VWC4
PDB IDs
3X1S
3X1U
9C62
9FGQ
1P9C
1P9D
1UEL
1YX4
1YX5
1YX6
2KDE
2KDF
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6MUN
6U19
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
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Chromatin Remodeling
Chromatin Organization
Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Metabolic Process
Macromolecule Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Deubiquitination
DNA Repair
Chromatin Binding
Protein Modification By Small Protein Removal
DNA Damage Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Transferase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Proteolysis
Nucleus
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Radiation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Modification By Small Protein Conjugation
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Transcription Coactivator Activity
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Double-strand Break Repair
Regulation Of DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Proteasomal Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Proteolysis
Macromolecule Catabolic Process
Post-translational Protein Modification
Regulation Of Proteolysis
Protein Catabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Positive Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Ubiquitin-protein Transferase Activity
Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin Protein Ligase Activity
Protein Polyubiquitination
Positive Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleus
Cytosol
Ubiquitin Protein Ligase Binding
Positive Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Enzyme Binding
Proteasome Binding
Cytoplasm
Cellular Response To Stress
Protein-folding Chaperone Binding
Ubiquitin Binding
Regulation Of Metabolic Process
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Protein Monoubiquitination
Ubiquitin Ligase Complex
Regulation Of Signal Transduction
Protein Destabilization
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Tagcloud (Intersection)
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