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H2BC3 and UBR7
Number of citations of the paper that reports this interaction (PubMedID
34739193
)
0
Data Source:
BioGRID
(enzymatic study)
H2BC3
UBR7
Description
H2B clustered histone 3
ubiquitin protein ligase E3 component n-recognin 7
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Chromosome
Cytosol
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Molecular_function
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Nucleosome Assembly
Biological_process
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Interacting Genes
49 interacting genes:
AKT1
ANAPC11
APP
BAP1
BARD1
BMI1
BRCA1
CDC20
CDK1
CDK2
CHD4
CREBBP
DNMT1
DYRK1A
EID1
EP300
ERCC6
FANCD2
HUWE1
KAT2A
KAT2B
KMT2A
KMT2C
KMT2D
MYB
PALB2
PIAS1
PSMD4
PTPN6
RHBDD2
RNF168
RNF2
RNF20
RNF40
RNF8
RPS6KA5
SMYD5
TSPYL5
UBE2A
UBR7
UHRF1
USP16
USP2
USP21
USP22
USP36
USP43
USP51
USP7
7 interacting genes:
H2BC3
H3C1
H3C15
ITGB3BP
OGT
UBE2E1
UBQLN4
Entrez ID
3018
55148
HPRD ID
07536
16602
Ensembl ID
ENSG00000276410
ENSG00000012963
Uniprot IDs
P33778
Q8N806
PDB IDs
3X1S
3X1U
9C62
9FGQ
Enriched GO Terms of Interacting Partners
?
Chromatin Remodeling
Chromatin Organization
Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Metabolic Process
Macromolecule Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Deubiquitination
DNA Repair
Chromatin Binding
Protein Modification By Small Protein Removal
DNA Damage Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Transferase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Proteolysis
Nucleus
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Radiation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Modification By Small Protein Conjugation
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Biosynthetic Process
Protein Ubiquitination
Transcription Coactivator Activity
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Double-strand Break Repair
Regulation Of DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Chromosome
Chromatin Organization
Structural Constituent Of Chromatin
Nucleosome Assembly
Nucleosome
Nucleosome Organization
Nucleoplasm
Protein-DNA Complex Assembly
Chromatin Remodeling
Protein Heterodimerization Activity
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Protein-containing Complex Assembly
Nuclear Proteasome Complex
Nucleus
Protein-containing Complex Organization
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein O-acetylglucosaminyltransferase Activity
Negative Regulation Of Autophagosome Maturation
ISG15 Transferase Activity
ISG15-protein Conjugation
Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
Non-canonical Inflammasome Complex Assembly
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By Glucose
Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
Cytosolic Proteasome Complex
Protein-containing Complex
Regulation Of Proteasomal Protein Catabolic Process
Carbon Catabolite Regulation Of Transcription
Regulation Of Transcription By Glucose
K48-linked Polyubiquitin Modification-dependent Protein Binding
NSL Complex
CENP-A Containing Chromatin Assembly
Regulation Of Macromolecule Metabolic Process
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Tagcloud (Intersection)
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