U2AF1 and NXF1

Number of citations of the paper that reports this interaction (PubMedID 11724776)
0

Data Source:
HPRD (two hybrid, in vitro)

		U2AF1	NXF1
Description		U2 small nuclear RNA auxiliary factor 1	nuclear RNA export factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex	Transcription Export Complex Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Nuclear RNA Export Factor Complex Nuclear Inclusion Body
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding RS Domain Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	RNA Export From Nucleus MRNA Export From Nucleus Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases
GWAS		Blood and toenail selenium levels ( 25343990)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		58 interacting genes: ALG13 AP1B1 AP2B1 CARNMT1 CHERP CIRSR CLK2 CPEB2 DHX38 EFHC2 EPB41 FILNC1 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRPK2 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA VPS26C WEE2-AS1 ZCCHC10 ZNF417 ZRANB2 ZRSR2	138 interacting genes: ALDOA ALYREF APOBEC3C AUNIP BACH2 BECN1 BICD2 BIN3 BIRC2 BLMH BTBD18 C10orf55 C1orf35 CAMK2G CCDC120 CCDC196 CCDC197 CCDC7 CDYL2 CEBPA CEP55 CLK2 CLK3 CPSF7 CSNK2A1 CTTN DDX50 DHX9 DMRTB1 DVL3 ECSIT EIF4A3 ELAVL4 ESRRA EXOSC8 FAM9A FTO GFAP GOLGA6L9 GPBP1 GTPBP2 HNRNPUL1 HOMEZ HOXA1 HSF2BP IMPA1 IPO11 IPO4 ISY1-RAB43 KATNBL1 KCTD5 KCTD7 KIF24 KRT31 KRT40 LCE3E LDOC1 LUZP4 MAGOH MAP1A MAP1B MBD3L1 MID2 MRNIP MTUS2 NKAPD1 NME1 NME4 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 PEG10 PIH1D2 PPP1R12C PRKAR1B PRPH PRR3 PRRC2B PURB QKI RAD51 RAE1 RALYL RAN RANBP2 RBFOX2 RBM15B RBM22 RBMX RBPMS REDIC1 RPRD1A SGTA SH2D3A SH3GLB2 SLAIN1 SNRPA SNW1 SPATC1L SRPK2 SRSF1 SRSF3 SRSF4 SRSF7 SRSF8 STRAP SYCP3 TBC1D14 TCP10L TEX9 TFIP11 THOC5 TIFA TNFAIP1 TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN1 UBQLN4 UPF3A VAPA VIM VPS28 WEE2-AS1 XIST ZBED2 ZC3HAV1 ZNF250 ZNF343 ZNF438
Entrez ID		7307	10482
HPRD ID		01871	04035
Ensembl ID		ENSG00000160201	ENSG00000162231
Uniprot IDs		Q01081 Q7Z780	Q59E96 Q9UBU9
PDB IDs		1JMT	1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7 4WYK 6E5U
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Nucleic Acid Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Nuclear Speck Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Nucleus Nucleoplasm Protein-RNA Complex Assembly Macromolecule Metabolic Process MRNA Binding U2-type Precatalytic Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process U12-type Spliceosomal Complex Negative Regulation Of RNA Splicing U2-type Spliceosomal Complex Positive Regulation Of RNA Splicing Precatalytic Spliceosome U1 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Negative Regulation Of RNA Metabolic Process Protein-containing Complex Assembly U2-type Prespliceosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process U2 SnRNP Commitment Complex Positive Regulation Of Viral Genome Replication Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA Splice Site Recognition Regulation Of RNA Metabolic Process Protein-containing Complex Organization MRNA 5'-splice Site Recognition T Cell Differentiation In Thymus	MRNA Transport RNA Transport Nucleobase-containing Compound Transport RNA Binding RNA Export From Nucleus MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Nucleic Acid Binding RNA Processing Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Intracellular Transport Nucleic Acid Metabolic Process Nuclear RNA Export Factor Complex Nucleoplasm Positive Regulation Of RNA Splicing Identical Protein Binding Import Into Nucleus Protein Binding Cellular Localization Nuclear Localization Sequence Binding Nuclear Pore Spliceosomal Complex Catalytic Step 2 Spliceosome Protein Import Into Nucleus Nucleobase-containing Compound Metabolic Process Nuclear Speck Positive Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Localization In Cell Protein Localization To Nucleus Exon-exon Junction Complex Establishment Of Protein Localization To Organelle Poly(A)+ MRNA Export From Nucleus Protein Localization To Organelle Nuclear Envelope Intracellular Protein Transport Negative Regulation Of MRNA Metabolic Process
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