U2AF1 and SRRM4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		U2AF1	SRRM4
Name		U2 small nuclear RNA auxiliary factor 1	serine/arginine repetitive matrix 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex	Nucleus
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding RS Domain Binding	RNA Binding MRNA Binding Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development Sensory Perception Of Sound RNA Splicing Cell Differentiation Neuron Maturation Regulation Of RNA Splicing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	None
GWAS		Blood and toenail selenium levels ( 25343990 )	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Facial morphology (factor 3, length of philtrum) ( 28441456 ) Loneliness ( 27629369 ) Loneliness (linear analysis) ( 27629369 ) Photic sneeze reflex ( 27182965 ) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576 ) Stroke ( 32693751 )
Interacting Genes		58 interacting genes: ALG13 AP1B1 AP2B1 CARNMT1 CHERP CIRSR CLK2 CPEB2 DHX38 EFHC2 EPB41 FILNC1 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRPK2 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA VPS26C WEE2-AS1 ZCCHC10 ZNF417 ZRANB2 ZRSR2	34 interacting genes: - AKAP17A ARL6IP4 C16orf87 C1orf35 CACNA1A CDC37 CLK1 CLK4 FAM9B LUC7L LUC7L2 LUZP4 MCRS1 PRPF38A RBM25 RBM39 RBMX2 RNPS1 RSRC1 SNIP1 SNRNP70 SREK1 SRRM1 SRSF11 SRSF4 TBC1D26 U2AF1 WDR5 ZNF124 ZNF286A ZNF699 ZRSR2 ZRSR2P1
Entrez ID		7307	84530
HPRD ID		01871	13897
Ensembl ID		ENSG00000160201	ENSG00000139767
Uniprot IDs		Q01081 Q7Z780	A7MD48 V5T9A0
PDB IDs		1JMT	Not available
GO Terms Enriched among Interactors		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Nucleic Acid Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Nuclear Speck Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Nucleus Nucleoplasm Protein-RNA Complex Assembly Macromolecule Metabolic Process MRNA Binding U2-type Precatalytic Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process U12-type Spliceosomal Complex Negative Regulation Of RNA Splicing U2-type Spliceosomal Complex Positive Regulation Of RNA Splicing Precatalytic Spliceosome U1 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Negative Regulation Of RNA Metabolic Process Protein-containing Complex Assembly U2-type Prespliceosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process U2 SnRNP Commitment Complex Positive Regulation Of Viral Genome Replication Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA Splice Site Recognition Regulation Of RNA Metabolic Process Protein-containing Complex Organization MRNA 5'-splice Site Recognition T Cell Differentiation In Thymus	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nuclear Speck Spliceosomal Complex RNA Binding MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process U2-type Prespliceosome U1 SnRNP MRNA Binding Regulation Of MRNA Metabolic Process Protein-RNA Complex Assembly U1 SnRNP Binding Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome NSL Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleoplasm Precatalytic Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex U2-type Prespliceosome Assembly Negative Regulation Of RNA Splicing U2 SnRNP Protein Serine/threonine/tyrosine Kinase Activity MLL1 Complex Histone H3Q5ser Reader Activity MRNA Splice Site Recognition Macromolecule Metabolic Process Negative Regulation Of Protein Refolding Histone H3K4me1 Reader Activity HSP90-CDC37 Chaperone Complex