PKNOX2 and HOXB1

Number of citations of the paper that reports this interaction (PMID 11972344)
11

Data Source:
HPRD (in vitro)

		PKNOX2	HOXB1
Gene Name		PBX/knotted 1 homeobox 2	homeobox B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton	Nucleus
	Molecular Function	DNA Binding Actin Monomer Binding Sequence-specific DNA Binding Actin Filament Binding	DNA Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Alcohol dependence ( 21956439 21703634) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Schizophrenia ( 22688191) Substance dependence ( 21298047)	Primary tooth development (number of teeth) ( 20195514)
Protein-Protein Interactions		1 interactors: HOXB1	8 interactors: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 SERPINA3
Entrez ID		63876	3211
HPRD ID		17857	00855
Ensembl ID		ENSG00000165495
Uniprot IDs		B7ZAF3 Q96KN3	P14653
PDB IDs			1B72
Enriched GO Terms of Interacting Partners?		Facial Nucleus Development Rhombomere 4 Development Rhombomere 5 Development Rhombomere Development Facial Nerve Structural Organization Pons Development Facial Nerve Morphogenesis Parasympathetic Nervous System Development Anatomical Structure Arrangement Autonomic Nervous System Development Neural Nucleus Development Cranial Nerve Development Nerve Development Embryonic Skeletal System Morphogenesis Metencephalon Development Embryonic Skeletal System Development Hindbrain Development Anterior/posterior Pattern Specification Skeletal System Morphogenesis	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Neuron Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Stem Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neurogenesis Regulation Of Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cell Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Cell Development Regulation Of DNA-templated Transcription In Response To Stress Organ Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Type I Interferon Production Negative Regulation Of RNA Biosynthetic Process Embryo Development Histone H2B Acetylation Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Negative Regulation Of Apoptotic Cell Clearance Pancreatic A Cell Development Nervous System Development Transcription, DNA-templated Pattern Specification Process RNA Biosynthetic Process
Tagcloud ?			blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes
Tagcloud (Difference) ?			blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes
Tagcloud (Intersection) ?