PKNOX2 and HOXB1

Number of citations of the paper that reports this interaction (PubMedID 11972344)
34

Data Source:
HPRD (in vitro)

		PKNOX2	HOXB1
Description		PBX/knotted 1 homeobox 2	homeobox B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Actin Monomer Binding Protein Binding Sequence-specific DNA Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Rhombomere Development Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21703634 21956439) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)	Body mass index ( 26426971) Colorectal or endometrial cancer ( 26621817) Hemoglobin levels ( 32327693) Keratoconus ( 33649486) Primary tooth development (number of teeth) ( 20195514) Waist circumference ( 28552196)
Interacting Genes		32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C YAP1	10 interacting genes: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 RCHY1 SERPINA3 ZNF835
Entrez ID		63876	3211
HPRD ID		17857	00855
Ensembl ID		ENSG00000165495	ENSG00000120094
Uniprot IDs		B7ZAF3 Q96KN3	P14653
PDB IDs			1B72
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Membrane Curvature Sensor Activity Transcription Corepressor Activity Late Endosome To Vacuole Transport Protein Domain Specific Binding Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT I Complex Establishment Of Protein Localization To Vacuole Macroautophagy Regulation Of MAP Kinase Activity Positive Regulation Of Exosomal Secretion Intracellular Protein Transport FAR/SIN/STRIPAK Complex Endosome Organization Regulation Of Exosomal Secretion Protein Localization To Vacuole Viral Budding Via Host ESCRT Complex Structural Constituent Of Nuclear Pore Viral Budding	Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Eye Development DNA Binding Transcription Coregulator Binding Sensory Organ Development DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Damaged DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex P53 Binding Negative Regulation Of Neuron Differentiation Chromatin DNA Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Acetyltransferase Activity Pattern Specification Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Cell Development Regulation Of RNA Metabolic Process Megakaryocyte Development Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hemopoiesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Acetyltransferase Activity Animal Organ Morphogenesis Regulation Of Neuron Differentiation Protein Acetylation Chromatin Activation Of Innate Immune Response Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process
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