PKNOX2 and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKNOX2	IQGAP1
Description		PBX/knotted 1 homeobox 2	IQ motif containing GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Actin Monomer Binding Protein Binding Sequence-specific DNA Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension
Pathways			Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21703634 21956439) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C YAP1	45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP
Entrez ID		63876	8826
HPRD ID		17857	04541
Ensembl ID		ENSG00000165495	ENSG00000140575
Uniprot IDs		B7ZAF3 Q96KN3	A0A0J9YXZ5 P46940
PDB IDs			1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Membrane Curvature Sensor Activity Transcription Corepressor Activity Late Endosome To Vacuole Transport Protein Domain Specific Binding Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT I Complex Establishment Of Protein Localization To Vacuole Macroautophagy Regulation Of MAP Kinase Activity Positive Regulation Of Exosomal Secretion Intracellular Protein Transport FAR/SIN/STRIPAK Complex Endosome Organization Regulation Of Exosomal Secretion Protein Localization To Vacuole Viral Budding Via Host ESCRT Complex Structural Constituent Of Nuclear Pore Viral Budding	Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion
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