PKNOX2 and CREBL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKNOX2	CREBL2
Description		PBX/knotted 1 homeobox 2	cAMP responsive element binding protein like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Actin Monomer Binding Protein Binding Sequence-specific DNA Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of D-glucose Import Positive Regulation Of Lipid Biosynthetic Process Protein Stabilization
Pathways
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21703634 21956439) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)	Height ( 31562340) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systemic lupus erythematosus ( 23273568)
Interacting Genes		32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C YAP1	6 interacting genes: CREBRF DDIT3 DNMT3L NFE2L2 PKNOX2 UBE2I
Entrez ID		63876	1389
HPRD ID		17857	07541
Ensembl ID		ENSG00000165495	ENSG00000111269
Uniprot IDs		B7ZAF3 Q96KN3	O60519
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Membrane Curvature Sensor Activity Transcription Corepressor Activity Late Endosome To Vacuole Transport Protein Domain Specific Binding Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT I Complex Establishment Of Protein Localization To Vacuole Macroautophagy Regulation Of MAP Kinase Activity Positive Regulation Of Exosomal Secretion Intracellular Protein Transport FAR/SIN/STRIPAK Complex Endosome Organization Regulation Of Exosomal Secretion Protein Localization To Vacuole Viral Budding Via Host ESCRT Complex Structural Constituent Of Nuclear Pore Viral Budding	PERK-mediated Unfolded Protein Response Regulation Of Response To Endoplasmic Reticulum Stress Response To Caloric Restriction Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein-DNA Complex ER-nucleus Signaling Pathway Integrated Stress Response Signaling Transcription Coregulator Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Endoplasmic Reticulum Unfolded Protein Response Regulation Of RNA Metabolic Process Positive Regulation Of Glutathione Biosynthetic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Prolactin Signaling Pathway Response To Unfolded Protein DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Determination Of Dorsal Identity CHOP-ATF4 Complex CHOP-ATF3 Complex Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Adaptive Immune Memory Response Involving T Cells And B Cells Regulation Of Cellular Response To Stress Modification-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription CHOP-C/EBP Complex Regulation Of Transcription By RNA Polymerase II Diaphragm Contraction Negative Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Vascular Associated Smooth Muscle Cell Migration RING-like Zinc Finger Domain Binding Epigenetic Programing Of Female Pronucleus Negative Regulation Of RNA Metabolic Process Adaptive Immune Memory Response Involuntary Skeletal Muscle Contraction Cellular Response To Nitrosative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation SUMO Ligase Complex HLH Domain Binding
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